Enhancing stereochemical diversity by means of microwave irradiation in the absence of solvent: Synthesis of highly substituted nitroproline esters via 1,3-dipolar reactions |
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Authors: | Díaz-Ortiz Angel de la Hoz Antonio Herrero M Antonia Prieto Pilar Sánchez-Migallón Ana Cossío Fernando P Arrieta Ana Vivanco Silvia Foces-Foces Concepción |
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Affiliation: | Area de Química Orgánica, Facultad de Química, Universidad de Castilla-La Mancha, E-13071 Ciudad Real, Spain. Angel.Diaz@uclm.es |
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Abstract: | Microwave irradiation induces the 1,3-dipolar cycloaddition of imines derived from alpha-aminoesters with beta-nitrostyrenes in the absence of solvent within 10-15 min. The reaction proceeds to give yields in the range 81-86% and three isomeric pyrrolidines are obtained in the cycloaddition. Consequently, the use of three imines and two beta-nitrostyrenes gives rise to a library of 18 nitroproline esters. The use of classical heating with longer reaction times (24 h) gives lower yields of products (below 50%) and only two stereoisomers can be detected in each reaction. |
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