中药单体对卵巢癌信号通路的调控作用

总结近年来有关中药单体对卵巢癌信号通路调控作用的研究进展。中药单体可以调控卵巢癌的多条信号通路,按照作用机制分类,主要包括对PI3K/AKT信号通路的调控(如淫羊藿苷、千金藤素、柚皮素等)、对JAK/STAT信号通路的调控(如白藜芦醇、槲皮素、莪术醇等)、对MAPK信号通路的调控(如原薯蓣皂苷、龙胆苦苷、二氢杨梅素等)、对Wnt/β-catenin信号通路的调控(如羟基红花黄色素A、丹皮酚、芹菜素等)、对Notch信号通路的调控(如双氢青蒿素、山萘酚、姜黄素等)、对NF-κB信号通路的调控(如人参皂苷Rg1、二氢丹参酮Ⅰ、白蔹素等)、对TLR4/MyD88信号通路的调控(如莱菔子素、白术内酯Ⅰ、姜黄素等)。中药单体可通过调控上述信号通路抑制卵巢癌细胞增殖,诱导细胞凋亡,阻滞细胞周期进程,抑制细胞迁移和侵袭等,从而发挥抗肿瘤作用。

Regulation effects of Chinese medicine monomer on ovarian cancer signaling pathway

The research progress of Chinese medicine monomer on the regulation of ovarian cancer signaling pathway in recent years is reviewed here. Traditional Chinese medicine monomer can regulate multiple signaling pathways of ovarian cancer. According to their mechanism of action, there are mainly seven types of regulation: the regulation of PI3 K/AKT signaling pathway(such as by icariin, cepharanthine, naringetol, etc.), the regulation of JAK/STAT signaling pathway(such as by resveratrol, quercetin, curcumol, etc.), the regulation of MAPK signaling pathway(such as by diosgenin, gentiopicrin, dihydromyricetin, etc.), the regulation of Wnt/β-catenin signaling pathway(such as by hydroxysafflor yellow A, paeonol, apigenin, etc.), the regulation of Notch signaling pathway(such as by dihydroartemisinin, kaempferol, curcumin, etc.), the regulation of NF-κB signaling pathways(such as by ginsenoside Rg1, dihydrotanshinone Ⅰ, ampelopsin, etc.), and the regulation of TLR4/MyD88 signaling pathways(such as by sulforaphane, atractylenolide Ⅰ, curcumin, etc.). These regulations can inhibit the proliferation of ovarian cancer cells, induce cell apoptosis, block cell cycle, inhibit cell migration and invasion ability, so that can play a corresponding anti-tumor role.