Cholinesterase inhibiting and antiplasmodial steroidal alkaloids from Sarcococca hookeriana |
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Authors: | Devkota Krishna Prasad Lenta Bruno Ndjakou Choudhary Muhammad Iqbal Naz Qamar Fekam Fabrice Boyom Rosenthal Philip Joseph Sewald Norbert |
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Affiliation: | Department of Chemistry, Organic and Bioorganic Chemistry, Bielefeld University, Bielefeld, Germany. devkotakpd@yahoo.com |
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Abstract: | Bioguided phytochemical investigation of Sarcococca hookeriana with respect to the cholinesterase enzyme inhibitory assay yielded two new pregnane-type steriodal alkaloids hookerianamide H (1) and hookerianamide I (2), along with three known alkaloids N(a)-methylepipachysamine D (3), sarcovagine C (4) and dictyophlebine (5). Their structures were determined with the aid of extensive spectroscopic analysis. All compounds showed good inhibitory activities against the enzymes acetylcholinesterase (IC(50) 2.9-34.1 microM) and butyrylcholinesterase (IC(50) 0.3-3.6 microM). These compounds also showed moderate antiplasmodial activity (IC(50) 2.4-10.3 microM) against the Plasmodium falciparum chloroquine resistant W2 strain. |
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