血清维生素D水平与原发性肾病综合征患者并发医院感染的关系

目的 探讨血清维生素D水平与原发性肾病综合征(PNS)患者并发医院感染的关系.方法 选取60例发生医院感染的PNS患者(院感组)和61例无医院感染的PNS患者(对照组).检测两组血清25羟维生素D325 (OH) D3]水平,对可能影响PNS患者合并医院感染的因素进行单因素及多因素分析.结果 有95.0％(115/121)的PNS患者存在25(OH)D3缺乏;院感组25 (OH) D3水平低于对照组,25(OH)D3重度缺乏者比例高于对照组(P均＜0.05);低25 (OH) D3及血清白蛋白水平是PNS患者并发医院感染的独立危险因素(P＜0.05).结论 PNS患者普遍存在维生素D缺乏,维生素D缺乏是PNS患者并发医院感染的独立危险因素之一.

Relationship between serum vitamin D level and nosocomial infections in patients with primary nephrotic syndrome

Objective To investigate the relationship between serum vitamin D level and nosocomial infections in patients with primary nephrotic syndrome (PNS).Methods A total of 60 PNS patients with nosocomial infections (infection group) and 61 PNS patients without nosocomial infections(control group) were enrolled in the study.Serum level of 25-hydroxyvitamin D3 25 (OH)D3] was detected in the two groups,and the potential factors influencing nosocomial infections were analyzed in PNS patients by univariate and multivariate analysis.Results 25 (OH) D3 deficiency was seen in 95.0％ (115/121) of PNS patients.Compared to the control group,the infection group had lower 25 (OH) D3 level and higher proportion of severe 25 (0H) D3 deficiency (all P ＜ 0.05).Low levels of 25 (OH) D3 and serum albumin were the independent risk factors for nosocomial infections in PNS patients (P ＜ 0.05).Conclusion Vitamin D deficiency is common among PNS patients,and it is one of independent risk factors for nosocomial infections in PNS patients.