热休克蛋白70在合并C型人格特征抑郁的乙肝相关性肝癌患者中的表达及临床意义

目的 探讨热休克蛋白70(HSP70)在合并C型人格特征抑郁HBV相关性肝癌患者中的表达情况及其临床意义.方法 选择60例行肝切除术的HBV相关性肝癌患者分为A组(C型人格特征抑郁)及B组(无C型人格特征抑郁),每组各30例.检测HSP70在患者肿瘤组织及血液中的表达,并比较两组患者肿瘤的复发情况及无病生存率,同时分析影响C型人格特征抑郁HBV相关性HCC患者预后的因素.结果 A组患者肿瘤组织HSP70 mRNA及蛋白的表达均高于B组(P<0.05);A组患者6个月、12个月及18个月无病生存率低于B组(P<0.05);HSP70 mRNA>3.726是C型人格特征抑郁HBV相关性肝癌患者无病生存期的影响因素(P<0.05).结论 具有C型人格特征抑郁的HBV相关性肝癌患者肝切除术后的预后较差,可能与HSP70高表达有关;HSP70可能可作为预测肝癌患者术后早期复发的生物学标志物.

Expression and clinical significance of heat shock protein 70 in patients with HBV-related liver cancer complicated with C-type personality trait depression

Objective To investigate the expression and clinical significance of heat shock protein 70(HSP70) in patients with HBV-related liver cancer complicated with C-type personality trait depression.Methods Sixty patients with HBV-related liver cancer who underwent hepatectomy were divided into Group A(with C-type personality trait depression) and Group B(without C-type personality trait depression),with 30 cases in each group.The HSP70 expressions of blood and tumor tissues were detected.The recrudescence and disease-free survival were compared between the two groups.The factors influencing the prognosis of patients with HBV-related liver cancer complicated with C-type personality trait depression was also analyzed.Results The expressions of HSP70 mRNA and protein in tumor tissues were higher in Group A compared to Group B(P<0.05).The 6-,12-and 18-month disease-free survival rates of Group A were significantly lower than those of Group B(P<0.05).HSP70 mRNA>3.726 was the factor influencing the prognosis of patients with HBV-related liver cancer complicated with C-type personality trait depression(P<0.05).Conclusion The prognosis of patients with HBV-related liver cancer complicated with C-type personality trait depression is worse after hepatectomy,which may be related to high HSP70 expression.HSP70 is probably used as a biomarker for predicting the postoperative early recurrence of patients with liver cancer.