Study of the nucleophilic substitution reactions of 2,4,10-trichloropyrimido[5,4-b]quinoline |
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Authors: | N. E. Britikova L. A. Belova A. S. Elina |
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Affiliation: | 1. S. Ordzhonikidze All-Union Scientific-Research Pharmaceutical-Chemistry Institute, Moscow
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Abstract: | A number of pyrimido[5,4-b]quinoline derivatives were synthesized. It is shown that in the reaction of 2,4,10-trichloropyrimido[5,4-b]quinoline (II) with strong nucleophilic reagents (OCH3 and SH) both of the halogens of the pyrimidine ring are replaced, while with amines substitution of the halogens of the pyrimidine ring proceeds successively; under more severe conditions, all three halogen atoms of II are replaced by amine residues. |
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