| Biocatalytic Synthesis of Highly Enantiopure 1,4-Benzodioxane-2-carboxylic Acid and Amide |
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| 作者姓名： | 刘军 王德先 郑企雨 王梅祥 |
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| 作者单位： | Beijing National Laboratory for Molecular Sciences, Laboratory for Chemical Biology, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China |
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| 基金项目： | Project supported by the Major State Basic Research Development Program （No. 2003CB716005）, the Ministry of Science and Technology, the National Science Foundation of China, and the Chinese Academy of Sciences. |
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| 摘 要： | Catalyzed by Rhodococcus erythropolis AJ270, a nitrile hydratase and amidase containing microbial whole-cell catalyst, at 10 ℃ and with the use of methanol as a co-solvent, nitrile and amide biotransformations produce 2S-1,4-benzodioxane-2-carboxamide and 2R-1,4-benzodioxane-2-carboxylic acid in high yields with excellent enantioselectivity.
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| 关 键 词： | 生物催化合成 1 4-苯二氧杂环乙烷-2-羧酸 1 4-苯二氧杂环乙烷-2-羧基氨化合物 生物转化 腈水合酶 酰胺酶 对映选择 |
| 收稿时间： | 2006-03-27 |
| 修稿时间： | 2006-03-272006-06-18 |
Biocatalytic Synthesis of Highly Enantiopure 1,4-Benzodioxane-2-carboxylic Acid and Amide |
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| LIU, Jun, WANG, De-Xian, ZHENG, Qi-Yu, WANG, Mei-Xiang.Biocatalytic Synthesis of Highly Enantiopure 1,4-Benzodioxane-2-carboxylic Acid and Amide[J].Chinese Journal of Chemistry,2006,24(11):1665-1668. |
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| Authors: | LIU Jun WANG De-Xian ZHENG Qi-Yu WANG Mei-Xiang |
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| Affiliation: | Beijing National Laboratory for Molecular Sciences, Laboratory for Chemical Biology, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China |
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| Abstract: | Catalyzed by Rhodococcus erythropolis AJ270, a nitrile hydratase and amidase containing microbial whole‐cell catalyst, at 10 °C and with the use of methanol as a co‐solvent, nitrile and amide biotransformations produce 2S‐1,4‐benzodioxane‐2‐carboxamide and 2R‐1,4‐benzodioxane‐2‐carboxylic acid in high yields with excellent enantioselectivity. |
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| Keywords: | 1 4-benzodioxane-2-carboxylic acid 1 4-benzodioxane-2-carboxamide biotransformation nitrile hydratase amidase enantioselectivity |
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