Effects of calcium antagonists on serotonin-dependent aggregation and serotonin transport in platelets of patients with migraine |
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| Authors: | Pukhal'skaya T G Kolosova O A Men'shikov M Y Vein A M |
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| Affiliation: | (1) Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow;(2) Department of Nervous Diseases, M. I. Sechenov Moscow Medical Academy, Moscow;(3) Institute ofExperimental Cardiology, Russian Cardiology Research-and-Production Complex, Russian Ministry of Health, Moscow |
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| Abstract: | Flunarizine and cinnarizine (IC50 6.8×10−6 and 2.8×10−5 M, respectively) inhibited3H-serotonin uptake by platelets. In higher doses, they blocked serotonin-induced platelet aggregation and stimulated3H-serotonin release from these cells. Imipramine did not affect serotonin-releasing effects of preparations. In all patients
cinnarizine was more potent in inhibiting serotonin uptake, and in half of the patients cinnarizine displayed higher activity
as an inductor of serotonin release.
Translated fromByulleten's Eksperimental'noi Biologii i Meditsiny, Vol. 130, No. 7, pp. 24–27, July, 2000 |
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| Keywords: | migraine platelets aggregation serotonin uptake and release flunarizine cinnarizine |
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