Cyclamate intake and cyclohexylamine excretion are not related to male fertility in humans |
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| Authors: | L Serra-Majem L Bassas R Garcí a-Glosas L Ribas C Ingl s I Casals P Saavedra A G Renwick |
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| Affiliation: |
a Department of Clinical Sciences, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain
b Community Nutrition Research Center, Science Park of the University of Barcelona, Barcelona, Spain
c Scientific Technical Laboratory, University of Barcelona, Barcelona, Spain
d Department of Mathematics, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain
e Clinical Pharmacology Group, School of Medicine, University of Southampton, Southampton, UK |
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| Abstract: | Cyclamate and its metabolite cyclohexylamine affect male fertility in high dose animal studies, but this affect has not been investigated in epidemiological studies. This paper reports the first epidemiological study designed to investigate the possibility of a relationship between cyclamate and cyclohexylamine and male fertility in humans, in which 405 cases of clinically defined infertility in men and 379 controls were surveyed. Semen evaluation, urine analysis for cyclamate and cyclohexylamine and dietary questionnaires were compared between cases and controls. No evidence was found of a significant association between cyclamate intake and male infertility; neither high cyclamate nor high cyclohexylamine excretion were associated with elevated risk. The lack of association remained after adjusting by age, area of residence, education, total energy intake and other variables. No significant correlations were observed between cyclamate intake, metabolism or excretion, and sperm count and motility. The results demonstrate no effect of cyclamate or cyclohexylamine on male fertility at the present levels of cyclamate consumption. |
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| Keywords: | cyclamate cyclohexylamine male fertility sperm concentration sperm motility case control study |
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