大肠癌中医证型分类研究

目的了解大肠癌中医证型构成分布主次,为临床治疗提供辨治方向。方法检索近10年网络数据库中西医学期刊,从383篇论文中收集中医治疗大肠癌确诊病例4 543例,对32种证型进行分类、归纳,分析比较中医证型的构成比及其差异。结果大肠癌常见中医证型依次是脾气虚弱型、湿热内蕴型、气血两虚型、肝肾阴虚型、气滞血瘀型和脾肾阳虚型。结论大肠癌发生、发展的中医主要病理机制与脾气虚弱、湿热内蕴、气血两虚、肝肾阴虚、气滞血瘀和脾肾阳虚等相关,其证型结构的排列主次可为制定大肠癌中医治疗方案的框架结构提供参考依据。

Classification study on the TCM syndrome of colorectal cancer

Objective To provide the clinical treatment direction of colorectal cancer for differentiating syndrome basing on understanding the structure of its TCM syndrome. Methods All of the papers were acquired by searching the network database about Chinese and western medical journals in recent l0 years. 4543 colorectal cancer cases derived from 383 papers were selected according to the diagnosis and treatment in traditional Chinese medicine. 32 syndrome types were conclud- ed and classified from these papers, while the proportion and differences of these types were analyzed and compared. Results The common syndromes of colorectal cancer were as follows： deficiency of spleen-Qi syndrome, damp-heat syndrome, and deficiency of both Qi and blood syndrome, Yin deficient of liver and kidney syndrome, Qi stagnation and blood stasis syn- drome, Yang asthenia of spleen and kidney syndrome. Conclusion The main pathological mechanism about the occurrence and development of colorectal cancer is related with deficiency of spleen-Qi syndrome, damp-heat syndrome, and deficiency of both Qi and blood syndrome, Yin deficient of liver and kidney syndrome, Qi stagnation and blood stasis syndrome, Yang asthenia of spleen and kidney syndrome. The structure of TCM syndrome will provide reference to make colorectal cancer treatment guidelines.