| 食管癌发生发展过程中P33/ING1、Survivin蛋白的表达 |
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| 引用本文： | 任秀花,李珊珊,阎爱华,张红燕. 食管癌发生发展过程中P33/ING1、Survivin蛋白的表达[J]. 郑州大学学报(医学版), 2004, 39(3): 378-380 |
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| 作者姓名： | 任秀花 李珊珊 阎爱华 张红燕 |
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| 作者单位： | 郑州大学基础医学院癌前期研究室,郑州,450052;河南省肿瘤病理重点实验室,郑州大学第一附属医院病理科,郑州,450052 |
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| 基金项目： | 河南省自然科学基金资助项目 0411040500;河南省科技攻关基金资助项目 0424410003;"十五"211工程"重点学科建设项目教重办(2002)第2号 |
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| 摘 要： | 目的探讨食管癌发生发展过程中P33/ING1、Survivin蛋白的表达及其与食管癌病理特征的关系.方法采用免疫组化SP法检测P33/ING1、Survivin蛋白在60例食管癌手术后大体标本中食管正常黏膜、单纯增生、不典型增生、原位癌及浸润癌组织的表达.结果P33/ING1蛋白从正常黏膜→单纯增生→不典型增生→原位癌→浸润癌呈渐进性低表达,而Survivin蛋白则呈渐进性高表达.正常黏膜与不典型增生、原位癌及浸润癌中P33/ING1、Survivin蛋白的表达差异有统计学意义(P＜0.05);P33/ING1蛋白表达情况与食管癌分化程度、浸润深度、淋巴结转移有关(P＜0.05).食管浸润癌组织中P33/ING1蛋白的低表达与Survivin蛋白的高表达呈负相关(r=-0.480,P＜0.01).结论P33/ING1、Survivin 2种蛋白与食管癌的发生发展密切相关,可作为肿瘤诊断的标志物.
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| 关 键 词： | 食管肿瘤 不典型增生 单纯增生 原位癌 食管 P33/ING1 Survivin |
| 修稿时间： | 2003-12-30 |
Expressions of P33/ING1 and Survivin protein in cancinogenesis and development of esophageal carcinoma |
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| REN Xiuhua ),LI Shanshan ),YAN Aihua ),ZHANG Hongyan ) ). Expressions of P33/ING1 and Survivin protein in cancinogenesis and development of esophageal carcinoma[J]. Journal of Zhengzhou University: Med Sci, 2004, 39(3): 378-380 |
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| Authors: | REN Xiuhua ) LI Shanshan ) YAN Aihua ) ZHANG Hongyan ) ) |
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| Affiliation: | REN Xiuhua 1),LI Shanshan 2),YAN Aihua 1),ZHANG Hongyan 2) 1) Department of Preaencerous Study,Zhengzhou University,Zhengzhou 450052 2) Henan Key Laboratory of Tumor Pathology,Department of Pathology,the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052 |
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| Abstract: | Aim:To detect the expressions of P33/ING1 and Surviv protein in different esophageal epithelial lesions, and analyze the relation between the expressions of P33/ING1 and Survivin and pathologic characteristics. Methods: Immunohistochemistry was used to detect the expression of P33/ING1 and Survivin in 60 cases of esophageal carcinoma with different epithelial lesions including normal, heperplasia, displasia, carcinoma in situ and invasive carcinoma. Results:The expression of Survivin was progressively increased and that of P33/ING1 was decreased from normal to invasive carcinoma. Significant differences were observed in expressions of P33/ING1 and Survivin between normal,displasia mucosa and carcinoma in situ, invasive carcinoma( P <0.01). Expression of P33/ING1 showed signifcant correlation with the infiltration depth, lymph node metastasis and differentiation of cancer tissues( P <0.05). The expression of P33/ING1 protein in esophageal invasive carcinoma was negatively correlated with that of Survivin protein( r =-0.480, P <0.01). Conclusion:The expression of P33/ING1 and Survivin is significantly related to the genesis and progression of esophageal carcinoma. They may be important markers for tumor diagnosis. |
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| Keywords: | esophageal neoplasm displasia heperplasia carcinoma in situ esophagus P33/ING1 Survivin |
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