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Distinct immunological signatures discriminate severe COVID-19 from non-SARS-CoV-2-driven critical pneumonia
Authors:Stefanie Kreutmair  Susanne Unger  Nicolás Gonzalo Núñez  Florian Ingelfinger  Chiara Alberti  Donatella De Feo  Sinduya Krishnarajah  Manuel Kauffmann  Ekaterina Friebel  Sepideh Babaei  Benjamin Gaborit  Mirjam Lutz  Nicole Puertas Jurado  Nisar P Malek  Siri Goepel  Peter Rosenberger  Helene A Häberle  Ikram Ayoub  Burkhard Becher
Affiliation:1. Institute of Experimental Immunology, University of Zurich, 8057 Zurich, Switzerland;2. German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Partner Site Freiburg, 79106 Freiburg, Germany;3. Department Internal Medicine I, Eberhard-Karls University, 72076 Tuebingen, Germany;4. Université de Nantes, CHU Nantes, Pôle Anesthésie Réanimations, Service d’Anesthésie Réanimation Chirurgicale, Hôtel Dieu, 44093 Nantes, France;5. German Centre for Infection Research (DZIF), Partner Site Tuebingen, 72076 Tuebingen, Germany;6. Department of Anesthesiology and Intensive Care Medicine, Eberhard-Karls University, 72076 Tuebingen, Germany;7. Toulouse Institute for Infectious and Inflammatory Diseases, Université de Toulouse, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale, UPS, 31024 Toulouse, France;8. Department of Immunology, University Hospital Zurich, 8006 Zurich, Switzerland;9. Department of Infectious and Tropical Diseases, Toulouse University Hospital, 31059 Toulouse, France
Abstract:
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  • Keywords:COVID-19  SARS-CoV-2  high-dimensional single cell analysis  immune profiling  immunophenotyping  spectral flow cytometry  biomarker  GM-CSF  HLA typing  peptide binding strength
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