血府逐瘀液对血小板与内皮细胞功能的影响

目的：研究血府逐瘀液对血以与内皮细胞功能的影响。方法；将不同浓度血府逐瘀液与血 矣体外培养人脐带内皮细胞共同作用，用放射免疫方法测定血小板膜表面ＧＰⅡｂ／Ⅲａ复合物和人脐静脉内皮细胞表面血栓调节蛋白（ＴＭ）分子数。结果：血府逐瘀液明显抑制二磷酸腺苷诱导的ＧＰⅡｂ／Ⅲａ复合物分子表达，对对照组比较有显著性差异，而血府逐瘀液对ＴＭ无明显影响。结论：血府逐瘀液阻断ＧＰⅡｂ／Ⅲａ复合物的暴露，可抑制ＡＤＰ

Effect of Xuefu Zhuyu Decoction on Function of Platelet and Endothelial Cell

OBJECTIVE: To explore the effect of Xuefu Zhuyu Decoction (XFZYD) on function of platelet and endothelial cell. METHODS: Through incubation of XFZYD, in different concentration, with platelet and human umbilical vein endothelial cell, the platelet membrane glycoprotein II b/III a complex and thrombomoduline (TM) of human umbilical vein endothelial cell were determined by radioimmunoassay. RESULTS: XFZYD in 40 mg/ml or 80 mg/ml could obviously inhibit the adenosine diphosphate induced glycoprotein II b/III a molecular expression, as compared with the control group, the difference was significant (P < 0.05, P < 0.01), but it did not influence the TM level significantly. CONCLUSION: XFZYD could inhibit the adenosine diphosphate induced activation of platelet through blocking the exposure of glycoprotein II b/III a complex.