| 胃癌耐药细胞株耐药谱的体外实验 |
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| 引用本文： | 蔡学君,张学庸.胃癌耐药细胞株耐药谱的体外实验[J].第四军医大学学报,1994,15(2):86-88. |
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| 作者姓名： | 蔡学君 张学庸 |
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| 作者单位： | 西京医院消化内科 |
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| 摘 要： | 观察胃癌细胞与抗肿瘤药作用后对不同药物耐的耐受情况，方法：胃癌细胞系ＳＧＣ７９０１在体外分别与长春新碱（ＶＣＲ），５氟尿嘧啶（５－Ｆｕ），阿霉素（ＡＤＭ）及氨甲喋呤（ＭＴＸ）作用，获得ＳＧＣ７９０１／ＶＣＲ，ＳＧＣ７９０１／ＡＤＭ，ＳＧＣ７９０１／５－Ｆｕ及ＳＧＣ７９０１／ＭＴＸ４个耐药细胞株。体外细胞毒性实验观察它们对ＶＣＲ，ＡＤＭ，５－Ｆｕ，ＭＴＸ，顺铂（ＣＤＤＰ）以及丝裂霉素Ｃ（ＭＭＣ）的敏
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| 关 键 词： | 胃肿瘤 药物耐受性 细胞株 |
In vitro study of anti-cancer agents resistant patterns of resistant hu-man gastric cancer cell lines |
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| CAI Xue-Jun,ZHANG Xue-Yong and FAN Dai-Ming.In vitro study of anti-cancer agents resistant patterns of resistant hu-man gastric cancer cell lines[J].Journal of the Fourth Military Medical University,1994,15(2):86-88. |
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| Authors: | CAI Xue-Jun ZHANG Xue-Yong and FAN Dai-Ming |
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| Affiliation: | CAI Xue-Jun,ZHANG Xue-Yong and FAN Dai-Ming Department of Gastroenterology,Xijing Hospital |
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| Abstract: | bjective:The resistant patterns of acquied resistant of gastric cancer cell lines to anticancer drugs were investigated.Methods:Four resistant sublines,SGC7901/VCR,SGC7901/5-Fu,SGC7901/ADM,SGC7901/MTX were established with gastric cancer SGC790l cell separately selected by vincristine(VCR),5-fluorouracil(5-Fu),adriamycin(ADM)andmethotrexate(MTX)in vitro.The susceptibility of sublines to VCR,ADM,5-Fu,MTX,cisplatin(CDDP)and mitomycin(MMC)were studied using MTT methods.Re-sults:Four resistant sublines were cross resistant to VCR , MTX , 5-Fu and MMC, resistant index varying from 2.9 to 1583.SGC7901/VCR and SGC7901/ADM cells were resistant to ADM by 1.5 and 101-fold re-spectively while SGC7901 /ADM and SGC7901/5-Fu resistant to CDDP by 6.3 and 2.5-fold.Conclusion:Four sublines are all multidrug resistance(MDR).Anticancer drugs can cause one-way cross resistance and two-waycross resistance. |
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| Keywords: | stomach neoplasm multidrug resistance cell sublines |
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