| 血管紧张素转换酶(ACE)基因多态性、血清ACE水平与2型糖尿病合并脑梗死的相关性研究 |
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| 引用本文： | 许岚,邓振霞,何戎华,吴懿玲,唐建英,穆会君,卜瑞芳,顾敏峰,王霞娟,蒋艳敏. 血管紧张素转换酶(ACE)基因多态性、血清ACE水平与2型糖尿病合并脑梗死的相关性研究[J]. 中国交通医学杂志, 2002, 16(1): 14-15 |
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| 作者姓名： | 许岚 邓振霞 何戎华 吴懿玲 唐建英 穆会君 卜瑞芳 顾敏峰 王霞娟 蒋艳敏 |
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| 作者单位： | 无锡市第一人民医院，无锡市第一人民医院，江苏省人民医院，无锡市第一人民医院，无锡市第一人民医院，无锡市第一人民医院，无锡市第一人民医院，无锡市第一人民医院，无锡市第一人民医院，无锡市第一人民医院 (214002)，(214002)，(214002)，(214002)，(214002)，(214002)，(214002)，(214 |
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| 摘 要： | 目的 :探讨血管紧张素转换酶 (ACE)基因多态性、血清ACE水平和 2型糖尿病合并脑梗死的关系。方法 :应用PCR方法检测 2型糖尿病患者和健康者ACE基因的缺失 /插入多态性并同时测定其血清ACE水平。结果 :糖尿病合并脑梗死组的DD基因型及D等位基因频率与非脑梗死组比较有显著性差异 ,且血清ACE水平在脑梗死患者中明显升高 ,与ACE基因多态性呈一致表现。结论 :糖尿病患者中DD基因型和D等位基因携带者具有患脑梗死易感性 ,并且在脑梗死患者ACE基因多态性与血清ACE水平呈一致表现
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| 关 键 词： | ACE基因多态性 2型糖尿病 脑梗死 |
A Correlation Between Angiotensin- converting Enzyme(ACE) Gene Polymorphism、Serum ACE Levels and Cerebral Infarction in Patients with Type 2 Diabetes Mellitus |
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| Xu Lan, Deng Zhen-xia,He Rong-hua,et al.. A Correlation Between Angiotensin- converting Enzyme(ACE) Gene Polymorphism、Serum ACE Levels and Cerebral Infarction in Patients with Type 2 Diabetes Mellitus[J]. Chinese Medical JOurnal of Communications, 2002, 16(1): 14-15 |
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| Authors: | Xu Lan Deng Zhen-xia He Rong-hua et al. |
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| Affiliation: | Xu Lan,1 Deng Zhen-xia,2He Rong-hua,et al. |
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| Abstract: | Objective: To clarify if angiotensin-converting enzyme (ACE) gene polymorphism, serum ACE levels attribute to the development of cerebral infarction in patients with type 2 diabetes mellitus. Methods:ACE genotypes were determined with PCR method in 137 patients with type 2 diabetes mellitus and 64 normal controls, meanwhile serum ACE levels were determined. Results:The DD genotype frequency was significantly higher in cerebral infarction group than that in group without cerebral infarction (P<0.05). Furthermore, the patients with cerebral infarction had higher serum ACE levels than those without cerebral infarction. Conclusions: ACE gene polymorphism attributes to development of cerebral infarction in patients with type 2 diabetes mellitus, mean serum ACE level in diabetic patients with cerebral infarction was significantly increased compared to its controls. |
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| Keywords: | ACE gene polymorphism Type 2 diabetes mellitus Cerebral infarction |
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