| 类风湿关节炎患者超声评估滑膜病变与血清血管内皮生长因子检测的相关性研究 |
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| 引用本文： | 陈勇,黄娴倩,陈立斌,尹凤英,龚丽敏,黄华,忻霞菲,周丽,覃文. 类风湿关节炎患者超声评估滑膜病变与血清血管内皮生长因子检测的相关性研究[J]. 现代实用医学, 2011, 23(9): 973-976. DOI: 10.3969/j.issn.1671-0800.2011.09.005 |
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| 作者姓名： | 陈勇 黄娴倩 陈立斌 尹凤英 龚丽敏 黄华 忻霞菲 周丽 覃文 |
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| 作者单位： | 1. 宁波市第一医院,宁波,315010
2. 宁波大学医学院 |
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| 摘 要： | 目的观察类风湿关节炎关节超声声像和血流动力学特点,探讨其与血清血管内皮生长因子(VEGF)水平和疾病活动度的关系。方法超声检查29例类风湿关节炎患者双肩、双肘、双腕、双侧掌指关节及近端指间关节、双膝关节,测量其滑膜厚度(US joint count SH、US index SH)、关节积液(US joint count SF、USindex SF)及RI值,并进行能量多普勒评分(TSS),同时对受检患者进行DAS28评分,采用酶联免疫吸附法检测血清中VEGF的含量。结果 RA患者血清VEGF与US joint SH、US index SH、US joint PD、TSS呈正相关,与RI呈负相关。RA患者DAS28评分与US joint SH、US index SH、US joint SF、US index SF、US jointPD、TSS呈正相关,与RI呈负相关。结论超声检查可以作为反映类风湿关节炎滑膜炎性病变及滑膜血管翳一种简单易行、安全有效的检查手段。
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| 关 键 词： | 超声检查 多普勒 类风湿关节炎 血管内皮生长因子 |
Correlation between ultrasonographic assessment of synovial lesions and serum level of vascular endothelial gro- wth factor in patients with rheumatoid arthritis |
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| CHEN Yong,HUANG Xianqian,CHEN Libin,YIN Fengying,GONG Limin,HUANG Hua,XIN Xiafei,ZHOU LI,QIN Wen. Correlation between ultrasonographic assessment of synovial lesions and serum level of vascular endothelial gro- wth factor in patients with rheumatoid arthritis[J]. Modern Practical Medicine, 2011, 23(9): 973-976. DOI: 10.3969/j.issn.1671-0800.2011.09.005 |
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| Authors: | CHEN Yong HUANG Xianqian CHEN Libin YIN Fengying GONG Limin HUANG Hua XIN Xiafei ZHOU LI QIN Wen |
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| Affiliation: | CHEN Yong,HUANG Xianqian,CHEN Libin,YIN Fengying,GONG Limin,HUANG Hua,XIN Xiafei,ZHOU Li,QIN Wen.(Ningbo First Hospital,Ningbo 315010,Zhejiang,China) |
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| Abstract: | Objective To observe joint ultrasonographic and hemodynamic characteristics in rheumatoid arthritis(RA),and their correlations with serum level of vascular endothelial growth factor(VEGF) and disease activity.Me-thods Twenty-nine RA patients were examined with ultrasound,including bilateral shoulder,elbow,wrist,meta-carpophalangeal(MCP) and proximal interphalangeal(PIP) joints of the hands as well as knee.Synovial hypertrophy(US joint count SH,US index SH),synovial fluid(US joint count SF,US index SF),resis... |
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| Keywords: | Ultralsonography doppler Rheumatoid arthritis Vascular endothelial growth factor |
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