脑血管病患者血浆内皮素水平的测定

目的探讨内皮素（ＥＴ）测定在脑血管病（ＣＶＤ）发病过程中的临床意义及与伴发症、病情的关系。方法用放射免疫分析法测定５８例ＣＶＤ患者的血浆总ＥＴ水平，并与５５例对照组比较。结果ＣＶＤ组血浆ＥＴ浓度明显升高（Ｐ＜０．００１），以病后第２周为分泌高峰；多发或再发梗死时高于单发病灶（Ｐ＜０．０５）；病情中、重型高于轻型（Ｐ＜０．０５）；伴发高脂血症者高于无高脂血症者（Ｐ＜０．０１）；有高血压病史者高于无高血压病史者（Ｐ＜０．０５）；有冠心病或高血压性心脏病史者高于无心脏病史者（Ｐ＜０．０５）；尿蛋白阳性者高于阴性者（Ｐ＜０．０５）。结论ＥＴ在ＣＶＤ的发生和发展中具有一定作用，与高血压、高血脂、冠心病、高血压性心脏病、肾脏损害存在一定的关系，ＥＴ含量变化与病情一致，可作为估计病情预后的指标之一。

The Detection of Plasm Endothelin Level in Patients with Cerebrovascular Disease

Objective To explore the significance and effects of endothelin (ET) in occurrence and development of cerebrovascular disease (CVD). Methods The plasma ET level was measured in 58 CVD patients by radioimmunoassay (RIA),and compared with 55 controls. Results The plasma ET level in patients was significantly higher than those in controls ( P <0.001),and the secretion peak of ET was in the second week after the occurrence of CVD.The ET level in patients with multiple focus and reoccurrence focus,serious patients' condition,hypertension,hyperlipoidemia,coronary heart disease and urine protein positive were higher than those in patients with signal focus and without hypertension,hyperlipoidemia,coronary heart disease and urine protein negative ( P <0.05,0.01). Conclusion The plasma ET might participate in the occurrence and development of CVD,and was related to the patients' conditions such as hypertension,hyperlipoidemia,coronary heart disease and kidney impairment.