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新型可控降解外科缝合线的研制
引用本文:王佃亮,王瑞玲. 新型可控降解外科缝合线的研制[J]. 生物技术通讯, 2013, 0(5): 702-704
作者姓名:王佃亮  王瑞玲
作者单位:王佃亮 (第二炮兵总医院药学部 北京 100088); 王瑞玲 (第二炮兵总医院消化科 北京 100088);
基金项目:国家自然科学基金(项目编号:81171201)
摘    要:目的:研制一种新型的可控降解手术缝合线,以满足不同伤口缝合的需要。方法:缝合线的最里层为壳聚糖纤维芯,中间为胶原层,最外层为羧甲基壳聚糖层;从里到外,各层厚度比例为2:x:(3-x),其中1〈x〈3。结果:不同型号的缝合线降解速度可控,适用于不同愈台期的伤口缝合,并具有很好的生物相容性和抗感杂性。结论:研制的新型缝合线操作方便,性价比高,植入体内后降解速度可控,伤口愈合快,不留明显疤痕,尤其适于野战环境条件下应用。

关 键 词:外科缝合线  可控降解  抗感染  生物相容性  野战环境

Development of a Novel Controllable Degradable Surgical Suture
WANG Dian-Liang,WANG Rui-Ling. Development of a Novel Controllable Degradable Surgical Suture[J]. Letters in Biotechnology, 2013, 0(5): 702-704
Authors:WANG Dian-Liang  WANG Rui-Ling
Affiliation:h a. Department of Pharmacy; b. Department of Gastroenterology; the Second Artillery General Hospital of PLA, Beijing 100088, China
Abstract:Objective: To develop a novel controllable degradable suture for suturing different wounds. Methods: It's chitosan fiber, collagen layer and carboxymethyl chitosan layer from inside to outside of the sure in turn, and correspondingly the thickness ratio is 2:x: (3-x), 1〈x〈3. Results: As the degradation rates of different sutures are controllable, different sutures that have good bioeompatibility and are anti-infectious are suitable for suturing different healing wounds. Conclusion: The novel suture which operation is simple and convenient is relatively cheap, controllable degradation, rapid wound healing, no obvious scar, and especially for field environment application.
Keywords:surgical suture  controllable degradation  anti-infection  biocompatibility  field environment
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