伤口修复中抑制瘢痕用功能敷料的研究进展

为实现皮肤伤口的无疤愈合，针对功能敷料在皮肤伤口愈合中所起到的抑制瘢痕作用，对国内外的相关研究进行概括总结。以伤口愈合过程为切入点，从瘢痕形成的影响因素，即外部环境和内部生物信号调控入手，系统分析了伤口愈合不同阶段的不同生理环境和需求下对抑制瘢痕敷料的性能要求。在炎症期、增殖期和重塑期3个阶段中，功能敷料分别以降低炎症反应、调节信号传导和促进组织再生的作用机制来抑制瘢痕的产生。认为瘢痕形成是一个动态连续而又复杂的过程，该过程涉及炎症细胞、角质形成细胞、成纤维细胞以及各类生长因子等物质，指出用于抑制瘢痕的功能敷料要想达到更好的效果，需要注重新型给药系统的研究和敷料结构的优化设计。

Research progress in functional dressings for scar inhibition in wound healing

In order to achieve scarless cutaneous wound healing, a summary of the relevant researches at home and abroad on the effect of functional dressings on inhibiting scarring was reviewed and summarized. The wound healing process was reviewed in the first place, concentrating on the factors affecting scar formation, namely external environment and internal biological signal regulation, the performance requirements of scar-inhibiting dressings under different physiological environments and demands at different stages of wound healing. At the three stages of inflammation, proliferation and remodeling, functional dressings inhibit scarring by reducing inflammatory response, regulating signal transduction and promoting tissue regeneration, respectively. Studies have shown that scar formation is a dynamic, continuous and complex process involving inflammatory cells, keratinocytes, fibroblasts and various growth factors. Therefore, in order to achieve better effect of functional dressings used to suppress scars, it is necessary to pay attention to the research of new drug delivery systems and the optimal design of dressings structures.