| 肝移植术后早期巨细胞病毒感染的先驱性治疗 |
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| 引用本文： | 李林,贾振庚,朱志军,沈中阳.肝移植术后早期巨细胞病毒感染的先驱性治疗[J].基础医学与临床,2005,25(6):525-528. |
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| 作者姓名： | 李林 贾振庚 朱志军 沈中阳 |
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| 作者单位： | 中国医学科学院,中国协和医科大学,北京,100005;天津市第一中心医院,移植外科,天津,300192;中日友好医院,普通外科,北京,100029;天津市第一中心医院,移植外科,天津,300192 |
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| 摘 要： | 目的 通过临床病例对照研究，寻求肝移植术后防治巨细胞病毒(CMV)感染的较好方法。方法 将63例原位肝移植患者分为预防性治疗组与先驱性治疗组，术后3个月内定期进行CMV-PP65定性和CMV-DNA定量检测，预防性治疗组均在术后2周时给于静脉更昔洛韦治疗，先驱性治疗组仅在检测阳性时给予更昔洛韦治疗。结果 预防性治疗组中17％(5／35)出现了CMV感染；先驱性治疗组中36％(10／28)出现了CMV感染。两组中全部病例均未发生CMV病。结论 肝移植术后早期采用先驱性治疗不增加巨细胞病毒病的发生率。
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| 关 键 词： | 肝移植 巨细胞病毒 先驱性治疗 |
| 文章编号： | 1001-6325(2005)06-0525-04 |
| 修稿时间： | 2005年1月10日 |
Pre-emptive treatment of cytomegalovirus infection in the early-phase after liver transplantation |
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| LI Lin,JIA Zhen-geng,ZHU Zhi-jun,SHEN Zhong-yang.Pre-emptive treatment of cytomegalovirus infection in the early-phase after liver transplantation[J].Basic Medical Sciences and Clinics,2005,25(6):525-528. |
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| Authors: | LI Lin JIA Zhen-geng ZHU Zhi-jun SHEN Zhong-yang |
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| Affiliation: | LI Lin~ 1,2,JIA Zhen-geng~ 3,ZHU Zhi-jun~ 2,SHEN Zhong-yang~ 2 |
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| Abstract: | Objective To find the good treatment of the CMV infection by a clinical control study. Methods Sixty-three Liver transplant recipients were divided into two groups ( prophylaxis group and pre-emptive group). All of them were tested for CMV by pp65 antigenemia and quantitative DNA-PCR assay weekly within 3 months after-transplantation. In the prophylaxis group all patients regularly received ganciclovir. In the pre-emptive group only patients with either assay positive received ganciclovir treatment. Results The incidence of CMV infection was 17%(5/35) and 36%(10/28)respectively. No CMV disease appeared in all patients (0/63). Conclusions Ganciclovir pre-emptive therapy is not associated with a higher incidence of CMV disease as compared with the prophylaxis therapy. |
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| Keywords: | liver transplantation cytomegalovirus pre-emptive treatment |
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