| 神经病变与痴呆发生的相关性为何在不同老龄段有差别？ |
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| 引用本文： | 陈良为.神经病变与痴呆发生的相关性为何在不同老龄段有差别？[J].第四军医大学学报,2010(3):27-29. |
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| 作者姓名： | 陈良为 |
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| 作者单位： | 第四军医大学基础部神经生物学教研室,全军神经科学研究所,陕西西安710032 |
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| 摘 要： | 老年性痴呆是发病率位居第一的严重神经退行性疾病。目前，临床上缺乏有效的防治手段，主要原因是痴呆的复杂病理发生机制还远没有搞清楚。研究老龄化、神经病变与痴呆发生的关系十分重要。本文针对2009年5月28日发表在《新英格兰医学杂志》（N Engl J Med）的一篇临床论文，梳理了不同老龄区段神经病变与痴呆发生出现差别的町能原因．提出需要进一步研究阐明问题的建议，以期引起同行争鸣。
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| 关 键 词： | 痴呆 老龄 神经病理 |
Age, neuropathology, and dementia |
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| Affiliation: | CHEN Liang- Wei( Department of Neurobiology, PLA Institute of Neurosciences, School of Basic Medicine, Fourth Military Medical University, Xi ＇an 710032, China ) |
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| Abstract: | Dementia or Alzheimer＇s disease is a severe neurodegenerative disease with high occurrence rate. There are few effective intervention methods for the prevention and treatment of dementia, and its related complicated pathological mechanism is still obscure until now. Actually, it is a crucial problem to study and elucidate the relationship of aging, neuropathy and dementia. This letter is corresponded to a clinical research article published in ＂N Engl J Med＂, May 28 issue in 2009, by explaining possible reasons that difference occurred between neuropathy and dementia in very old patient groups, and for the purpose of further peer- discussion. |
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| Keywords: | dementia aging neuropathology |
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