镇惊泻火合剂治疗广泛焦虑症临床研究

目的观察镇惊泻火合剂治疗广泛焦虑症的临床疗效及安全性。方法将60例病例随机分为中药组和对照组各30例,分别给予镇惊泻火合剂和盐酸帕罗西汀治疗。两组疗程均为8周,观察临床疗效及汉密尔顿焦虑评定量表(HAMA)评分变化情况,并采用不良反应量表(TESS)观察不良反应情况。结果中药组、对照组总有效率分别为90.3%、90.0%;组间临床疗效比较,差异无统计学意义(P>0.05)。两组治疗前后组内比较,HAMA评分差异均有统计学意义(P<0.05);组间治疗后比较,HAMA评分差异无统计学意义(P>0.05)。两组不良反应发生情况及TESS评分差异有统计学意义(P<0.05)。结论镇惊泻火合剂治疗广泛焦虑症疗效好,不良反应少。

Clinical research on "Zhenjing Xiehuo Mixture" for generalized anxiety

Objective To observe the clinical efficacy and safety of "Zhenjing Xiehuo Mixture" in the treatment of generalized anxiety.Methods Sixty cases were randomized into two groups: Chinese medicine group in which 30 cases were treated by "Zhenjing Xiehuo Mixture",and control group in which 30 cases were treated by Paroxetine hydrochloride,with the course of 8 weeks.The clinical efficacy and scores of HAMA were observed,and the adverse reaction was detected by TESS.Results The overall effective rate was 90.33% in Chinese medicine group and 90.0% in control group,without a significant difference between the two groups(P>0.05).There were significant differences in HAMA scores in both the two groups between before and after treatment(P<0.05);after treatment,there was no significant difference in HAMA score between the two groups(P>0.05).The differences in adverse reaction and TESS score were significant in both of the two groups(P>0.05).Conclusion "Zhenjing Xiehuo Mixture" has positive effect on generalized anxiety,with less adverse reaction.