可溶性细胞间黏附分子-1在原发性肝癌患者血清中的表达及其与肝纤维化的关系

目的:探讨可溶性细胞间黏附分子-1(sICAM-1)在原发性肝癌(PHC)患者血清中的水平及其与肝纤维化的关系。方法:采用ELISA方法测定45例PHC患者、30例良性肿瘤患者和35例健康查体者血清sICAM-1和肝纤维化四项(PCⅢ、Ⅳ-C、LN、HA)水平,并分析sICAM-1与肝纤维化之间的关系。结果:PHC组血清sICAM-1和肝纤维化四项(PCⅢ、Ⅳ-C、LN、HA)水平均显著高于良性肿瘤组和正常对照组,相比较有显著性差异(P<0.05);而良性肿瘤组和正常对照组各指标比较差异无统计学意义(P>0.05);血清sICAM-1含量与PCⅢ、Ⅳ-C、LN、HA含量呈显著正相关性(r=0.683、0.575、0.573、0.539,P<0.05)。结论:检测血清sICAM-1的水平对判定PHC患者的病情、为肝癌的早期诊断和治疗有着重要的临床意义。

Expression of serum sICAM-1 in patients with primary hepatocellular carcinoma and its relationship with liver fibrosis

AIM: To explore the clinical value of serum soluble intercellular adhesion molecule-1(sICAM-1) in patients with primary hepatocellular carcinoma(PHC) and its relationship with liver fibrosis.METHODS: The serum sICAM-1,PCⅢ,Ⅳ-C,LN and HA level of 45 cases of patients with PHC,30 cases of benign tumor and 35 cases of healthy people were determined by ELISA,the relationship between sICAM-1 and liver fibrosis was analyzed.RESULTS: The serum sICAM-1,PCⅢ,Ⅳ-C,LN and HA levels of the PHC group were significantly higher than that of the benign tumor group and normal control group,compared the difference was significant(P<0.05);The serum markers was no significant difference between the benign tumor group and normal control group(P>0.05);The serum sICAM-1 was positively correlated with the PC Ⅲ,Ⅳ-C,LN and HA(γ=0.683,0.575,0.573 and 0.539,P<0.05).CONCLUSION: Detection of serum sICAM-1 has important clinical significance for assessing the PHC patient’ s condition,early diagnosing and treating liver cancer.