基于新型拼接光子晶体光纤的SPR葡萄糖浓度传感器

本文提出了一种基于表面等离子体共振(SPR)技术的光纤传感器并应用于葡萄糖浓度检测。采用光纤熔接机拼接多模光纤-光子晶体光纤-光子晶体光纤-多模光纤(MPPM)的结构,然后利用磁控溅射在其表面沉积金膜。对传感区的金膜进行巯基乙胺修饰,采用戊二醛固定葡萄糖氧化酶(GOD),使传感器具备了葡萄糖特异性识别功能,并实现了低浓度葡萄糖传感,在0-0.8 mg/mL的浓度范围内表现出良好的线性关系,并且获得了29.61 nm/(mg/mL)葡萄糖灵敏度,拟合系数达到了~0.954。得益于其易制备、良好的生物相容性以及优异的传感性能,该光纤SPR传感器有望成为生物医学领域中具有发展潜力的传感器之一。

SPR glucose concentration sensor based on novel cascaded photonic crystal fiber

In this paper, an optical fiber sensor based on surface plasmon resonance (SPR) technology is proposed and applied to the detection of glucose concentration. The structure of multimode fiber photonic crystal fiber photonic crystal fiber multimode fiber (MPPM) is spliced by fiber fusion machine, and then gold film is deposited on its surface by magnetron sputtering. The gold film in the sensing area was modified with mercaptoacetamide, and glutaraldehyde was used to fix glucose oxidase (GOD), so that the sensor had the function of glucose specific recognition, and realized low concentration glucose sensing. It showed a good linear relationship in the concentration range of 0-0.8 mg / ml, and obtained 29.61 nm / (mg / ml) glucose sensitivity, and the fitting coefficient reached ~ 0.954. Thanks to its easy preparation, good biocompatibility and excellent sensing performance, the optical fiber SPR sensor is expected to become one of the sensors with development potential in the biomedical field.