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| 肺心合剂对肺动脉高压模型大鼠的影响 | |
| 引用本文： | 杨茂农,王飞,胥方元.肺心合剂对肺动脉高压模型大鼠的影响[J].中国中西医结合急救杂志,2003,10(3):164-166. |
| 作者姓名： | 杨茂农 王飞 胥方元 |
| 作者单位： | 1. 四川省人民医院,四川,成都,610072 2. 成都中医药大学 3. 泸州医学院附属医院 |
| 基金项目： | 四川省中医药管理局科研基金资助项目 ( 960 3 1) |
| 摘 要： | 目的：探讨肺心合剂对野百合碱(MCT)诱发肺动脉高压模型大鼠的治疗作用。方法：利用MCT制备大鼠肺动脉高压模型。雄性Wistar大鼠60只，随机分为正常对照组、模型组、硝苯吡淀组以及肺心合刑高、中、低剂量组，每组10只。分别于制模后14d灌胃相应药物，连续用药8d。采用有心导管术测定肺血流动力学参数，计算平均肺动脉压(mPAP)；处死动物后取肺脏称取肺湿质量，计算肺渗出指数和有心肥厚指数。结果：肺心合剂和硝苯吡淀都能明显降低肺动脉高压大鼠的mPAP、肺渗出指数和有心肥厚指数(P＜0．05或P＜0．01)，以肺心合剂大剂量组效果最好。结论：肺心合剂能有效降低肺动脉高压，改善心功能。 |
| 关 键 词： | 肺心合剂 肺动脉高压 大鼠 野百合碱 肺血流动力学 肺动脉压 慢性肺源性心脏病 |
| 文章编号： | 1008-9691(2003)03-0164-03 |
| 修稿时间： | 2003年3月23日 |
Effect of Feixin mixture(肺心合剂) on monocrotaline induced pulmonary hypertension in rats |
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| YANG Maonong ,WANG Fei ,XU Fangyuan ..Effect of Feixin mixture(肺心合剂) on monocrotaline induced pulmonary hypertension in rats[J].Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care,2003,10(3):164-166. | |
| Authors: | YANG Maonong WANG Fei XU Fangyuan |
| Affiliation: | YANG Maonong 1,WANG Fei 2,XU Fangyuan 3. 1. The People's Hospital of Sichuan Province,Chengdu 610072,Sichuan,China, 2. Chendu University of Traditional Chinese Medicine,China, 3. Affiliated Hospital of Luzhou Medical College,China |
| Abstract: | Objective: To explore the effect of Feixin mixture on pulmonary hypertension (PAHT). Methods: Adult male Wistar rats were given a single dose of subcutaneous monocrotaline(MCT, 50 mg/kg ) to induce the model of pulmonary hypertension. Sixty cases were randomly divided into normal contral group, PAHT mold group, FXM group and nifedipine group ( n =10). Then the rats were treated with gastric infusion of normal saline, FXM or nifedipine in 14th days respectively. The parameters of pulmonary hemodynamics were monitored by Gould3400 polygraph system through the cannulation of polyvinyl tube. Right ventricle and left ventricle added with interventricular septum weight ratio, the lung wet weight and body weight ratio were measured. Results: FXM and nifedipine significantly inhibited the progression of pulmonary artery pressure and decreased the right heart index and reduced the seepage out of the lung ( P <0 05 or P <0 01). The effect of high dose FXM group were better. Conclusion: FXM is able to reduce the pulmonary hypertension and improved the heart function. |
| Keywords: | monocrotaline pulmonary hypertension Feixin mixture |
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