| 外周血白细胞核基质蛋白检测在造血系统恶性肿瘤中的应用 |
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| 引用本文： | 刘峰 李冠武. 外周血白细胞核基质蛋白检测在造血系统恶性肿瘤中的应用[J]. 中国现代医学杂志, 1997, 7(6): 4-5,7 |
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| 作者姓名： | 刘峰 李冠武 |
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| 作者单位： | 广东汕头大学医学院第二附属医院血液内科!515031(刘峰，叶坤照)，广东汕头大学医学院肿瘤分子生物学研究室(李冠武，温博贵，钟叔平) |
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| 摘 要： | 采用高盐抽提方法制备正常人、慢性粒细胞白血病、慢性淋巴细胞白血病及恶性组织细胞病患者外周血白细胞核基质蛋白，经ＳＤＳ－ＰＡＧ电泳分析，发现不同来源的白细胞，其核基质蛋白表达存在显著差异，主要表现在分子量为２１０ＫＤ、１３５ＫＤ、１１ＫＤ、４６ＫＤ和２１ＫＤ的条带上。该方法简便，对于研究造血系统恶性肿瘤外周血白细胞核基质蛋白有显著意义。
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| 关 键 词： | 慢性 白血病 白细胞 核基质蛋白 恶性肿瘤 |
THE APPLICATION AND DETECTION OF THE NMPs OF THE PERIPHERAL WHITE CELL IN THE MALIGNANCE OF HEMATOPOIETIC SYSTEM |
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| Liu Feng,et al.. THE APPLICATION AND DETECTION OF THE NMPs OF THE PERIPHERAL WHITE CELL IN THE MALIGNANCE OF HEMATOPOIETIC SYSTEM[J]. China Journal of Modern Medicine, 1997, 7(6): 4-5,7 |
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| Authors: | Liu Feng et al. |
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| Abstract: | The NMPs (nuclear matrix proteins) were prepared by the method of high salt extracting from the white blood cell of normal human, patients with CMI,, CLL and malignant histiocytosis and were subjected to SDS - PAGE.The patterns of electrophoresis show that there are differences in NMPs' protein band, with their molecular weight 210KD, 135KD, 110KD, 46KD, and 21KD. The simple and convenient method would be of value in researching the NMPs of the peripheral white cell in the malignance of hematopoietic system. |
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| Keywords: | CML Malignant Histiocytosis White cell Nuclear matrix proteins |
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