德国洋甘菊总黄酮对糖尿病小鼠的降血糖作用研究

目的研究德国洋甘菊中总黄酮对糖尿病小鼠的降血糖作用。方法将糖尿病小鼠随机分为5组:模型组、阳性组(盐酸二甲双胍150 mg/kg)、德国洋甘菊低(78.86 mg/kg)、中(157.73 mg/kg)、高(315.46 mg/kg)剂量组。连续灌胃给药4w后,测定小鼠体重、空腹血糖、糖化血清蛋白、血清胰岛素,分别测定各组小鼠口服葡萄糖0、30、60、120 min后的血糖值,并计算曲线下面积(area underthe curve,AUC)。结果与模型组比较,德国洋甘菊总黄酮各剂量组小鼠体重均有增加,差异有统计学意义(P0.05);德国洋甘菊总黄酮中、高剂量组小鼠空腹血糖降低,差异有统计学意义(P0.05);中、高剂量组小鼠糖耐量降低,差异有统计学意义(P0.05);中、高剂量组小鼠GSP水平降低,差异有统计学意义(P0.05);高剂量组小鼠胰岛素增加,差异有统计学意义(P0.05)。结论德国洋甘菊总黄酮对糖尿病小鼠有一定的治疗作用。

Study on the hypoglycemic effect of total flavonoids from Matricaria chamomilla on diabetic mice

Objective To study the hypoglycemic effect of total flavonoids from Matricaria chamomilla on diabetic mice. Methods Diabetic mice were randomly divided into 5 groups: model group, the positive group (administered with metformin hydrochloride, 150 mg/kg), total flavonoids from Matricaria chamomilla low dose group (78.86 mg/kg), total flavonoids from Matricaria chamomilla medium dose group (157.73 mg/kg) and total flavonoids from Matricaria chamomilla high dose group (315.46 mg/kg). After 4 weeks, body weight, fasting blood glucose (FBG), glycosylated serum protein (GSP) and serum insulin (INS) were measured.and the blood glucose values of the mice in each group after oral glucose 0, 30, 60 and 120 min were measured respectively. The area under the curve (AUC) was calculated as the change in glucose tolerance. Results Compared to the model group, the body mass of each group had significantly different (P<0.05), FBG significantly decreased in the medium and high dose group (P<0.05), the level of glucose tolerance significantly decreased in the medium and high dose group (P<0.05), the level of GSP significantly decreased in the medium and high dose group (P<0.05), the level of INS significantly decreased in the high dose group (P<0.05). Conclusion The total flavone of Matricaria chamomilla has certain hypoglycemic effect on diabetic mice.