抗磷脂综合征的围产期抗凝治疗

抗磷脂综合征(APS)是一组以弥漫性动静脉血栓形成、病理妊娠和持续性抗磷脂抗体阳性为特征的综合征。APS能增加复发性流产、早产、死产、子痫前期、胎儿生长受限等妊娠并发症的发生率。不利的妊娠结局和妊娠期血栓形成之间有关联。围产期APS的治疗主要是对症治疗、防止再次发生血栓和病理妊娠。低剂量阿司匹林和肝素能改善APS的妊娠结局。

Perinatal anticoagulation therapy for obstetric antiphospholipid syndrome

Antiphospholipid syndrome（APS）is classified as one associated with thrombosis and/or pathological pregnancy and being persistently positive for antiphospholipid antibodies.APS can increase pregnancy complications，such as recurrent pregnancy loss，premature birth，stillbirth，intrauterine death，preeclampsia，and fetal growth restriction.An association is found between adverse pregnancy outcome and thrombophilias.Treatment for perinatal APS are mainly symptomatic treatment，preventing the recurrence of thrombosis and pathological pregnancy.The use of low-dose aspirin and heparin has improved the pregnancy outcome in obstetric antiphospholipid syndrome.