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A pharmacology-based comparison of the activity of albendazole and flubendazole against Echinococcus granulosus metacestode in sheep |
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| Authors: | L Ceballos G Virkel C Elissondo C Canton J Canevari G Murno G Denegri C Lanusse L Alvarez |
| Affiliation: | 1. Laboratorio de Farmacología, Centro de Investigación Veterinaria de Tandil (CIVETAN), CONICET, Facultad de Ciencias Veterinarias, UNCPBA, Campus Universitario, 7000 Tandil, Argentina;2. Laboratorio de Zoonosis Parasitarias, Departamento de Biología, Facultad de Ciencias Exactas y Naturales, Universidad Nacional de Mar del Plata (UNMdP), Funes 3250, 7600 Mar del Plata, Argentina and Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina |
| Abstract: | Cyst echinococcosis (CE) is a zoonotic disease caused by the larval stage of the Echinococcus granulosus helminth parasite. The work reported here aimed to compare the efficacy of albendazole (ABZ) and flubendazole (FLBZ) against CE in naturally infected sheep. Additionally, their comparative pharmacokinetic behaviour and the assessment of serum liver enzymes activities were studied. Twelve (12) naturally infected sheep were allocated to the following experimental groups: unmedicated control group, FLBZ-treated and ABZ-treated. |
| Keywords: | Cyst echinococcosis Albendazole Flubendazole Pharmacokinetics Efficacy |
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