The Risk of Cancer in Patients with Benign Anal Lesions: A Nationwide Population-based Study |
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Authors: | Pei-Chang Lee Yu-Wen Hu Man-Hsin Hung Chun-Chia Chen Han-Chieh Lin Fa-Yauh Lee Yi-Ping Hung Vincent Yi-Fong Su Sang-Hue Yen Cheng-Hwai Tzeng Tzeon-Jye Chiou Chia-Jen Liu |
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Affiliation: | 1. Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital, Taiwan;2. School of Medicine, National Yang-Ming University, Taipei, Taiwan;3. Cancer Center, Taipei Veterans General Hospital, Taiwan;4. Institute of Public Health, National Yang-Ming University, Taipei, Taiwan;5. Division of Hematology and Oncology, Department of Medicine, Taipei Veterans General Hospital, Taiwan;6. Department of Chest Medicine, Taipei Veterans General Hospital, Taiwan;g Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University Hospital, Yilan, Taiwan;h Department of Internal Medicine, National Yang-Ming University Hospital, Yilan, Taiwan |
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Abstract: | ObjectiveTo evaluate the risk of cancer among patients diagnosed with hemorrhoids and benign anal inflammatory lesions.MethodsA population-based, retrospective cohort study was conducted that included patients diagnosed with hemorrhoids or benign inflammatory anal lesions (eg, anal fissure, fistula, and perianal abscesses) that were registered in the National Health Insurance Research Database in Taiwan between January 1, 2000 and December 31, 2010. Standardized incidence ratios (SIRs) were calculated to compare the cancer incidence of these patients to the general population.ResultsDuring a median observation period of 6.23 years, 3080 cancers developed among 70,513 hemorrhoid patients, with a follow-up period of 438,425.6 person-years, entailing the SIR of 1.52 (95% confidence interval CI], 1.47-1.58). Increased cancer risk (SIR 1.16; 95% CI, 1.11-1.21) was still noted even after excluding the first year of observation. Significant long-term risk for colorectal cancer (SIR 1.50; 95% CI, 1.35-1.66) and prostate cancer (SIR 1.40; 95% CI, 1.17-1.66) was observed after corrections were made for multiple comparisons. In contrast, there was no remarkable increase in cancer risk for patients with inflammatory anal lesions when cancers detected within the first year of diagnosis were excluded.ConclusionThe presence of hemorrhoids is associated significantly with a long-term risk of developing colorectal cancer or prostate cancer. In contrast, benign inflammatory anal lesions do not appear to increase the risk of malignancy. |
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Keywords: | benign anal lesions hemorrhoids cancer risk |
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