Anticholinergic activity in mice and receptor-binding properties in rats of a series of synthetic tropane derivatives |
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Authors: | ZG Gao WY Cui BY Liu CG Liu L Wang |
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Affiliation: | Department of Cardiology, GB Pant Hospital, New Delhi. |
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Abstract: | AlF4- has long been known to associate with and activate the GDP-bound alpha subunits of heterotrimeric G-proteins. Recently the small guanine nucleotide binding protein Ras has also been shown to associate with AlF4- in the presence of stoichiometric amounts of its GTPase activating protein (GAP). Here we present the isolation of a stable Ras x GDP- x AlF4- x GAP ternary complex by gel filtration. In addition, we generalise the association of AlF4- with the small GTP-binding proteins by demonstrating ternary complex formation for the Cdc42, Rap and Ran proteins in the presence of their respective GAP proteins. |
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