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Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder |
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| Authors: | Ferreira Manuel A R O'Donovan Michael C Meng Yan A Jones Ian R Ruderfer Douglas M Jones Lisa Fan Jinbo Kirov George Perlis Roy H Green Elaine K Smoller Jordan W Grozeva Detelina Stone Jennifer Nikolov Ivan Chambert Kimberly Hamshere Marian L Nimgaonkar Vishwajit L Moskvina Valentina Thase Michael E Caesar Sian Sachs Gary S Franklin Jennifer Gordon-Smith Katherine Ardlie Kristin G Gabriel Stacey B Fraser Christine Blumenstiel Brendan Defelice Matthew Breen Gerome Gill Michael Morris Derek W Elkin Amanda Muir Walter J McGhee Kevin A Williamson Richard MacIntyre Donald J MacLean Alan W |
| Affiliation: | Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA. |
| Abstract: | To identify susceptibility loci for bipolar disorder, we tested 1.8 million variants in 4,387 cases and 6,209 controls and identified a region of strong association (rs10994336, P = 9.1 x 10(-9)) in ANK3 (ankyrin G). We also found further support for the previously reported CACNA1C (alpha 1C subunit of the L-type voltage-gated calcium channel; combined P = 7.0 x 10(-8), rs1006737). Our results suggest that ion channelopathies may be involved in the pathogenesis of bipolar disorder. |
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