| 微小RNA在肿瘤研究方面的进展 |
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| 引用本文： | 陈蕾.微小RNA在肿瘤研究方面的进展[J].国际肿瘤学杂志,2009,36(7). |
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| 作者姓名： | 陈蕾 |
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| 作者单位： | 湖北省武汉市华中科技大学附属协和医院血液内科,430022 |
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| 摘 要： | 微小RNA(miRNA)通过特异性碱基对互补调节其靶mRNA的基因表达,参与细胞的增殖、分化与凋亡过程.肿瘤细胞中miRNA表达水平与正常细胞有显著差异.miRNA可以表现为致癌基因和抑癌基因,与肿瘤的发生发展密切相关,并有望成为新的治疗靶点.
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| 关 键 词： | 微RNA 肿瘤 癌基因 抑癌基因 |
Recent progress on the research of microRNA in cance |
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| CHEN Lei.Recent progress on the research of microRNA in cance[J].Journal of International Oncology,2009,36(7). |
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| Authors: | CHEN Lei |
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| Abstract: | MicroRNA (miRNA) regulate the expression of target mRNA according to the specific base pairing. They are involved in proliferation,differentiation and apoptosis of cells. The expression of miRNA has distinct differences between normal tissues and cancers, miRNA can be oncogenes but also suppressor genes, they play an important role in cancer. And miRNA are promising to be a new therapeutic target. In this review, we will discuss the advance in the research of miRNA in cancer. |
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| Keywords: | MicroRNAs Neoplasms Oncogenes Genes tumor suppressor |
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