| 长必安干预大肠癌转移的基因芯片研究 |
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| 引用本文： | 罗森飙,沈汉澄.长必安干预大肠癌转移的基因芯片研究[J].浙江中西医结合杂志,2003,13(11):670-672. |
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| 作者姓名： | 罗森飙 沈汉澄 |
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| 作者单位： | 1. 浙江省上虞市人民医院,上虞,312300
2. 浙江省立同德医院 |
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| 基金项目： | “九五”国家科技攻关课题基金资助项目( NO:96 90 6 0 70 3) |
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| 摘 要： | 目的：探讨中药长必安抑制大肠癌转移的机制。方法：应用含227个靶基因芯片分析长必安干预后的大肠癌裸鼠转移模型的基因表达谱差异。结果：发现p47LBC、DKPZP434A2322与syn-thetase-like protein mRNA等3个基因在肠癌转移模型发生转移和未发生转移的癌组织中存在表达差异，长必安对后两个基因产生上调作用。结论：中药长必安对多个癌转移相关基因可能有调控作用。
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| 关 键 词： | 长必安 大肠癌 肿瘤转移 基因芯片 基因表达谱 中医药疗法 动物模型 |
| 修稿时间： | 2003年5月12日 |
Micro-array Study for the Effect of Changbi'an Co. on the Colorectai Cancer Metastasis |
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| LUO senbiao,SHEN Hancheng Shangyu City Peoples Hospital in Zhejiang Province. Shangyu.Micro-array Study for the Effect of Changbi''''an Co. on the Colorectai Cancer Metastasis[J].Zhejiang Journal of Integrated Traditional Chinese and Western Medicine,2003,13(11):670-672. |
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| Authors: | LUO senbiao SHEN Hancheng Shangyu City Peoples Hospital in Zhejiang Province Shangyu |
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| Abstract: | Objective: To investigate the effect mechanism of Changbi'an on the colorectal cancer metastasis. Methods:The difference of genes expression in the nude mice model with colorectal cancer metastasis was investigated by applying the cDNA micro array after treated with Changbi'an. Results: There were different of the p47LBC, DKFZP434A2322 and synthetase like protein mRNA genes expression in the tissues with colorectal cancer metastasis or without metastasis. Changbi'an could improve those genes expression. Conclusion:Changbi'an may play a certain role on regulating multiple metastasis relating oncogene. |
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| Keywords: | colorectal cancer metastasis gene expression micro array Changbi'an |
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