Easy saponification by metal silanolates: application in SPPS and in (S)-5-hydroxynorvaline preparation |
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| Authors: | Ewelina Minta |
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| Affiliation: | Laboratoire d’Aminoacides, Peptides et Protéines, CNRS-UMR 5810, Université Montpellier I et II, 34095 Montpellier Cedex 5, France |
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| Abstract: | Alkali metal trimethylsilanolates, TMSO−, M+, has been used for efficient conversion of methyl esters into their corresponding anhydrous acid salts under mild non-aqueous conditions. This strategy has been applied to SPPS for the preparation of neurotoxin cyclic analogues and in (S)-5-hydroxynorvaline synthesis. |
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| Keywords: | Sodium and potassium silanolates SPPS Aminoacids Glu Asp Selective deprotection |
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