冠心病患者介入治疗后不同时期白细胞介素-8、C反应蛋白及血浆P选择素的变化

目的:探讨血清白细胞介素8(IL8)、C反应蛋白(CRP)以及血浆P选择素(PS)在冠心病(CHD)介入治疗(PCI)后不同时期的变化。方法:对行PCI的CHD患者(PCI组)应用免疫吸附反应法(ELISA法)测定IL8、CRP、PS在介入治疗前,治疗后5min、1h、24h、1个月的变化。结果:PCI组术前及术后各时点的血清IL8、CRP、PS水平较同时点的对照组显著增加(P<0.05);PCI组IL8、CRP水平在术后5min、1h,PS水平在术后5min较术前、术后其他时点显著增加(P<0.01);IL8、CRP与PS之间呈正相关(r=0.54,r=0.49,P<0.05);血清IL8、CRP及血浆PS水平,多支病变高于双支病变,双支病变高于单支病变。结论:血清IL8、CRP、血浆PS水平在CHD患者PCI后一过性增高;术前IL8、CRP、PS水平测定对CHD病变程度有较强的预测价值,IL8、CRP与PS之间存在着相关性。

Changes of serum interleukin-8, C-reactive protein, and plasma P-selectin in patients with coronary artery disease in different stages after percutaneous coronary intervention

Objective:To study the changes and clinical significance of serum interleukin-8(IL-8), C-reactive protein (CRP) and plasma P-selectin (PS) in patients with coronary artery disease(CAD) in different stages after percutaneous coronary intervention (PCI). Method:The concentrations of serum IL-8,CRP and plasma PS were measured by enzyme linked immunosorbent assay (ELISA) before PCI and 5 min,1 h,24 h,1 month after PCI. Result:In PCI group, the levels of serum IL-8 ,CRP, and plasma PS before PCI and different stages after PCI were significantly higher than that of control group(P<0.05);the levels of IL-8,CRP were higher at 5 min,1 h after PCI, the levels of PS were higher at 5 min after PCI than those of before PCI and other stages after PCI (P<0.01); the levels of IL-8,CRP had positive correlation with the level of PS (r=0.54, r=0.49,P<0.05).In multiple-vessel lesions group levels of serum IL-8, CRP, and plasma PS were higher than those in two-vessel lesion group. In two-vessel lesion group, the levels of IL-8 ,CRP, and PS were higher than those of in one-vessel group. Conclusion:Levels of serum IL-8, CRP, and Plasma PS temporarily increased at 5 min and 1 h after PCI. It has valuable forecast for the extent of atherosclerosis to detect the levels of serum IL-8, CRP, and PS before PCI. There are correlation among serum IL-8, CRP and plasma Ps.