| 梅毒患者外周血T淋巴细胞亚群的检测及临床意义 |
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| 引用本文： | 朱慧兰,陈荣章,武明昌,杨日东,林蔼,叶兴东,徐广坤. 梅毒患者外周血T淋巴细胞亚群的检测及临床意义[J]. 中国麻风皮肤病杂志, 2000, 16(3): 156-158 |
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| 作者姓名： | 朱慧兰 陈荣章 武明昌 杨日东 林蔼 叶兴东 徐广坤 |
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| 作者单位： | 1. 广州市皮肤病防治所性病科,510095
2. 中山医科大学第三附属医院皮肤性病科,510063 |
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| 摘 要： | 目的：了解梅毒患者的细胞免疫功能状态及使用免疫调节剂治疗对它的影响。方法：应用流式细胞仪检测了４４例梅毒患者外周血的ＣＤ３＾＋、ＣＤ４＾＋、ＣＤ８＾＋及ＣＤ４＾＋／ＣＤ８＾＋比值。结果：梅毒患者外周血ＣＤ４＾＋及ＣＤ４＾＋／ＣＤ８＾＋比值明显低于正常对照组，而ＣＤ８＾＋则显著高于正常人对照组（Ｐ〈０．０１），活动期梅毒外周血ＣＤ４＾＋／ＣＤ８＾＋比值低于恢复期（Ｐ〈０．０５），单纯使用抗梅毒治疗的
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| 关 键 词： | 梅毒 T淋巴细胞亚群 流式细胞仪 治疗 |
Determination of peripheral blood T-lymphocyte subgroup in syphilitic patients and its clinical significance |
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| Zhu Huilan ,Chen Rongzhang ,Wu Mingchang ,et al.. Determination of peripheral blood T-lymphocyte subgroup in syphilitic patients and its clinical significance[J]. China Journal of Leprosy and Skin Diseases, 2000, 16(3): 156-158 |
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| Authors: | Zhu Huilan Chen Rongzhang Wu Mingchang et al. |
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| Affiliation: | Zhu Huilan 1,Chen Rongzhang 2,Wu Mingchang 1,et al. 1Department of Venerology,GuangZhou Institute of Dermatology and Venerology,Guangzhou,510095, 2Third Affiliated Hospital,Sun Yet Sen University of Medical Sciences,Guangzhou,510036 |
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| Abstract: | Objective:To understand the cellular immunity function in patients with syphilis and the effect of immunomodular preparations (Esberitox N or TNF).Method:T lymphocyte subpopulation in the peripheral blood of 44 patients with syphilis were detected by flow cytometry. Forty healthy people were recruited as control.Results:1)The number of CD4 and CD4 /CD8 ratio were significantly lower and the number of CD8 was remarkably higher as compared with those in the control group (P<0.01);2)CD4 /CD8 ratio in active phase of the disease was lower than that in stationary and recovery phases (P<0.05);3)The number of CD4 and CD4 /CD8 ratio in active phase simply treated with antibiotics (PG or cephalosporins) were lower than those treated by antibiotics (PG or cephalosporins) in combination with immunomodular preparations (Esberitox N or TNF)(P<0.05).Conclusions:This study showed cellular immunity in patients with early syphilis was prominently suppressed, and indicated that treatment with immunomodular preparations (Esberitox N or TNF) may be useful in recovering cellular immunity function for early syphilis patients. [ |
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| Keywords: | syphilis T lymphocyte subgroup flow cytometry |
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