| Abstract: | Cognitive and neurobiological accounts of clinical anxiety and depression were examined via event-related brain potentials (ERPs) recorded from patients with panic disorder and healthy controls as they performed an old/new recognition memory task with emotionally negative and neutral words. The emotive connotation of words systematically influenced control subjects'--but not patients'--ERP effects at prefrontal sites in a latency range (–300-500 ms) generally assumed to reflect greater contribution of automatic than controlled memory processes. This provides evidence for dysfunctional inhibitory modulation of affective information processing in panic disorder. The ERP effects after 700 ms, however, suggest that some patients may adopt conscious strategies to minimize the impact of these early processing abnormalities on overt behaviors. (PsycINFO Database Record (c) 2010 APA, all rights reserved) |
