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| 应用冻干羊膜进行的硬脑膜修补 | |
| 引用本文： | 张念平,刘舫,田学文,张勇.应用冻干羊膜进行的硬脑膜修补[J].中国组织工程研究与临床康复,2010,14(3). |
| 作者姓名： | 张念平 刘舫 田学文 张勇 |
| 作者单位： | 1. 山东中医药大学,山东省济南市,250355 2. 山东省中医院神经外科,山东省济南市,250014 3. 山东省中医院病理科,山东省济南市,250011 |
| 摘 要： | 背景:羊膜在眼科领域的应用比较普遍,许多研究表明羊膜移植并不引起急性免疫排斥反应,这提示其可以作为修补硬脑膜缺损的安全材料.目的;探讨羊膜作为硬脑膜修补材料的可能性.方法:将豚鼠颅顶部冠状缝后、矢状缝两侧开骨窗.在右侧骨窗下切除硬脑膜,缺损处用冻干羊膜修补.左侧骨窗下切除硬脑膜后再将切下的硬脑膜修补复位,做为对照.分别在术后第15,30,60,90天处死,取修补部位脑膜标本,苏木精-伊红染色,进行组织学观察.结果与结论:术后所有动物行为无异常,皮肤切口如期愈合,无感染、无皮下积液、无脑脊液漏.植入物逐渐被降解并被一层结缔组织覆盖,修补部位与大脑表面无粘连.术后15 d较多散在的成纤维细胞出现在修补材料内.术后30 d部分修补材料消失,修补材料中心部位纤维结缔组织增生,未见炎细胞浸润.术后60 d修补材料大部分消失,被增生及轻度变性的纤维结缔组织替代,周围见少量的异物巨细胞.术后90 d修补材料呈胶原变性,其周围见骨化组织及变性的纤维结缔组织,未见炎细胞浸润.动物实验证明冻干羊膜是一种安全、有效的硬脑膜修补材料. |
| 关 键 词： | 冻干羊膜 硬脑膜 修补材料 豚鼠 生物材料 |
Freeze-dried amniotic membrane for repair of dural defects |
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| Zhang Nian-ping,Liu Fang,Tian Xue-wen,Zhang Yong.Freeze-dried amniotic membrane for repair of dural defects[J].Journal of Clinical Rehabilitative Tissue Engineering Research,2010,14(3). | |
| Authors: | Zhang Nian-ping Liu Fang Tian Xue-wen Zhang Yong |
| Affiliation: | Zhang Nian-ping1,Liu Fang 2,Tian Xue-wen 2,Zhang Yong 3 1Sh,ong University of Traditional Chinese Medicine,Jinan 250355,Sh,ong Province,China,2Department of Neurosurgery,Sh,ong Provincial Hospital of Traditional Chinese Medicine,Jinan 250014,3Department of Pathology,Jinan 250011 |
| Abstract: | BACKGROUND:Amnion has been widely used in ophthalmology.Numerous studies have suggested that amnion transplantation did not induce acute immunologic rejection.These indicated that amnion transplantation can be used as a safe material for repair of dural defects.OBJECTIVE:To study the probability of freeze-dried amniotic membrane(FDAM)as a dural substitue.METHODS:Each of the guinea pigs underwent bilateral parietal craniectomy behind the coronal suture and beside the midline to expose the dura.On the right s... |
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