| 新生儿重组酵母乙型肝炎疫苗免疫11年效果随访 |
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| 引用本文： | 吴维寿,孙超美,姜铭波,张国华,胡凯,牟文,宿飞,周子荣. 新生儿重组酵母乙型肝炎疫苗免疫11年效果随访[J]. 职业与健康, 2011, 27(17): 1924-1926 |
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| 作者姓名： | 吴维寿 孙超美 姜铭波 张国华 胡凯 牟文 宿飞 周子荣 |
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| 作者单位： | 上海市黄浦区疾病预防控制中心免疫规划科,200011 |
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| 摘 要： | 目的评价新生儿接种国产重组(酵母)乙型肝炎疫苗后11年的免疫效果。方法对上海市黄浦区1997年出生并接种重组(酵母)乙型肝炎疫苗的新生儿于免疫后11年进行随访,采血检测乙型肝炎病毒表面抗原(HBsAg),乙型肝炎病毒表面抗体(抗-HBs)和乙型肝炎病毒核心抗体(抗-HBc),1998年开始对乙型肝炎免疫人群开展急性乙型肝炎发病监测。结果随访检测HBsAg阳性率为0.54%,较免疫前本底的HBsAg阳性率呈较大幅度下降,疫苗保护率为88.05%(95%可信区间为85.17%～91.17%)。接受重组(酵母)乙型肝炎疫苗免疫的对象中,无一例急性乙型肝炎病例报告。结论重组(酵母)乙型肝炎疫苗有较好的远期保护效果,免疫人群尚无再免疫的需要。
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| 关 键 词： | 重组(酵母)乙型肝炎疫苗 乙肝表面抗原 保护效果 |
A Follow-up on Efficacy of Immunization of Yeast-derived Recombinant Hepatitis B Vaccine after 11 Years |
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| WU Wei-shou,SUN Chao-mei,JIANG Ming-bo,ZHANG Guo-hua,HU Kai,MU Wen,SU Fei,ZHOU Zi-rong. A Follow-up on Efficacy of Immunization of Yeast-derived Recombinant Hepatitis B Vaccine after 11 Years[J]. Occupation and Health, 2011, 27(17): 1924-1926 |
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| Authors: | WU Wei-shou SUN Chao-mei JIANG Ming-bo ZHANG Guo-hua HU Kai MU Wen SU Fei ZHOU Zi-rong |
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| Affiliation: | WU Wei-shou,SUN Chao-mei,JIANG Ming-bo,ZHANG Guo-hua,HU Kai,MU Wen,SU Fei,ZHOU Zi-rong(Huangpu District Center for Disease Control and Prevention,Shanghai,200011,China) |
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| Abstract: | [Objective]To evaluate the immune efficacy after 11 years' Immunization of domestic yeast-derived recombinant hepatitis B vaccine in newborns. [Methods]A follow-up on children who were born in 1997 and vaccinated with domestic yeast-derived recombinant hepatitis B vaccine at their birth was implemented to test the HBsAg,anti-HBs and anti-HBc.The incidence of acute hepatitis B among subjects with hepatitis B vaccinated was monitored since 1998. [Results]The positive rate of HBsAg was 0.54%,compared with that... |
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| Keywords: | yeast-derived recombinant hepatitis B vaccine HBsAg Protective effect |
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