环境低硒暴露对农村老年人群血脂水平影响的初步研究

目的了解环境低硒暴露与农村老年人群血脂水平的相互关系。方法随机抽取4个现场现有老年认知研究队列中65～80周岁研究对象共198名,采集指甲和清晨空腹静脉血液样品,采用2,3—二氨基萘荧光法测定硒含量,采用酶生化试剂盒检测血浆中总胆固醇(TC)、甘油三酯(TG)含量、高密度脂蛋白胆固醇(HDL-C)的含量。结果各现场人群指甲硒、血硒的总体水平与外环境硒水平一致;低硒地区人群与适宜硒地区人群间血脂水平存在明显差异;总人群血浆硒含量与高密度脂蛋白胆固醇(HDL-C)及甘油三酯(TG)含量负相关有显著统计学意义(P<0.05),指甲硒含量与血浆HDL-C含量负相关有显著统计学意义(P<0.05);不同地区人群血浆硒及指甲硒含量与血脂指标间的相关性分析结论不尽一致。结论环境低硒暴露可能与农村老年人血脂水平有关。

Preliminary Study on the Relationship between Low Environmental Selenium Exposure and Serum Lipids Level among the Elderly Rural Chinese

Objectives To explore the relationship between low environmental selenium exposure and serum lipids level among the elderly rural Chinese.Methods 198 subjects aged 65 to 80 were randomly sampled from the available Elderly Cognitive Cohort from 4 study on-sites,collecting both nail and early morning intravenous blood samples.The trace amount of selenium was detected by 2,3-diaminonaphthalenet fluorometric determination method.Serum total cholesterol(TC),triglyceride(TG),high density lipoprotein-cholesterol(HDL-C) were detected using enzymatic bio-chemic determination kits.Results Both the nail and serum selenium overall levels were consistent with environmental selenium level.There were significant difference in serum lipid level between low environmental selenium exposure population and feasible environmental selenium exposure population.Negative correlation was statistically significant between serum selenium and HDL-C,between serum selenium and TG,and also between nail selenium and serum HDL-C in overall population.The correlation between serum selenium and serum lipid indices or serum selenium and nail selenium with serum lipid indices were not consistent among the 4 study sites.Conclusion Low environmental selenium exposure may associate with serum lipid level among the elderly rural Chinese.