云芝多糖的实验药理研究

本文对云芝菌体多糖(PV-1)及滤液多糖(PV-4)作了抗肿瘤及对免疫功能的影响等实验研究。结果,两种多糖均使小鼠胸腺缩小,脾重增加,并有提高巨噬细胞吞噬的作用。但抑瘤作用较弱。PV-1能增强戊巴比妥钠的作用,使小鼠睡眠时间延长。两种多糖毒性均很小,小鼠腹腔注射 LD50 PV-1为2750mg/kg,PV-4为2883mg/kg。

Pharmacological Studies on Polysaccharides of Polystictus Versicolor

Inhibition of polysaccharides on sarcoma 180 and the immune response of polysaccharides were studied. Polysaccharides of polystictus versicolor used in this experiment were obtained from its mycelium ( PV -1 ) and culture medium ( PV -4 ) . when the polvsaccharides were administered intraperitoneally in daily dose of 10-100mg/kg to sarcoma 180 bearing mice for 10 to 35 days, it was found to have a faint inhibition. PV - 4 couLd not potentiate the inhibition of cyclophosphamide on sarcoma 180, on the contrary it decreased the effect, when daily dose 200mg/kg of polysaccharides was continued for 3 days, they have caused infant mice to lose the thymus weight but to gain the spleen weight. PV - 1 prolong the time of sleeping induced by pentobarbtal. In the normal mice, as well as in these mice suffering from impaired liver caused by carbontetrachloride, when PV - 1 was administered subcutaneously in dose of 100mg/kg for 7 days, it has been found to enhance the phagocytosis of microphage, Studies of acute toxicity have shown that the LD50 of PV - 1 is 2750 mg/kg, PV - 4 is 2883 mg/kg for intraperitoneal administration in mice,