| 重组人内皮抑素两种给药途径抑制角膜新生血管的实验研究 |
| |
| 引用本文： | 李维义,高晓唯,郭继华,任兵. 重组人内皮抑素两种给药途径抑制角膜新生血管的实验研究[J]. 农垦医学, 2008, 30(3): 185-188 |
| |
| 作者姓名： | 李维义 高晓唯 郭继华 任兵 |
| |
| 作者单位： | 石河子大学医学院,新疆石河子,832002;解放军第474医院眼科医院,新疆乌鲁木齐,830000;解放军第474医院眼科医院,新疆乌鲁木齐,830000 |
| |
| 摘 要： | 目的:研究重组人内皮抑素(recombinant human endostatin,rHES,恩度)两种给药途径对碱烧伤诱导大鼠角膜新生血管的抑制作用. 方法:48只Wistar大鼠随机分为4组:A组(12只眼),对照组,不做处理;B组(12只眼),角膜碱烧伤后球结膜下注射生理盐水0.05ml,隔日1次;C、D组(各12只眼),右眼角膜碱烧伤后分别应用100mg/ml重组人内皮抑素点眼,4次/日和球结膜下注射0.05ml,隔日1次治疗.观察各组角膜新生血管的生长情况,免疫组化检测VEGF蛋白的表达.结果:C组、D组在碱烧伤后各时间点新生血管面积均小于B组,C组、D组与B组新生血管面积的差异有统计学意义(P<0.05);D组较C组对新生血管的抑制作用略强,差异无统计学意义(P>0.05).碱烧伤后第16天免疫组织化学检查显示除C组与D组间,其余各两两比较VEGF蛋白量差异有统计学意义,C组与D组VEGF蛋白量差异无统计学意义(P>0.05).结论:点眼和球结膜下注射重组人内皮抑素(恩度)即均可有效抑制CNV.
|
| 关 键 词： | 重组人内皮抑素 角膜新生血管 |
The inhibitory effect of recombinant human endostatinon to rat corneal neovascularization by two deferent medication ways |
| |
| Li Weiyi,Gao Xiaowei,Guo Jihua,Ren bing. The inhibitory effect of recombinant human endostatinon to rat corneal neovascularization by two deferent medication ways[J]. Agricultural Reclamation Medicine, 2008, 30(3): 185-188 |
| |
| Authors: | Li Weiyi Gao Xiaowei Guo Jihua Ren bing |
| |
| Affiliation: | Li Weiyi1,2 Gao Xiaowei2 Guo Jihua2 Ren bing2(1.Postgraduate Research Institute,Shihezi university School of medicine,Xinjiang Shihezi,832000,2.Department of Ophthalmology,No.474 ltospital of Chinese PLA,Xinjiang Unurnqi,830011) |
| |
| Abstract: | Objective: To investigate the inhibitory effect of recombinant human endostatin(rHES) on alkaline-induced rat corneal neovascularization by eye drop and subconjunctival injection.Methods:Corneal neovascularization animal model was established using 1 mol/L NaOH solution in rat.48 Wistar rats were divided into 4 groups:A group(12eyes),control groups,normal eyes;B group(12eyes),N.S.were injected into subconjunctival tissues one time every other day after alkaline burn;C group(12 eyes)and D group(12eyes)were r... |
| |
| Keywords: | recombinant human endostatin corneal neovascularization |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
