| 强直性脊柱炎遗传学研究进展 |
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| 引用本文： | 王立新,袁峰.强直性脊柱炎遗传学研究进展[J].中国优生与遗传杂志,2011(11):8-9. |
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| 作者姓名： | 王立新 袁峰 |
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| 作者单位： | 徐州医学院附属医院骨科; |
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| 摘 要： | 强直性脊柱炎是一种具有高度遗传倾向的血清阴性脊柱关节病。既往的研究主要报道HLA-B27基因与AS的强相关性,但近年来大量的研究提示除HLA-B27基因外,可能还存在其他的MHC类和非MHC类基因与AS相关。本文综述了强直性脊柱炎的遗传学因素的研究进展,为其诊断、预防和治疗提供新的思路。
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| 关 键 词： | 强直性脊柱炎 遗传学进展 基因 |
Genetic research progress of ankylosing spondylitis |
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| WANG Li-xin,YUAN Feng..Genetic research progress of ankylosing spondylitis[J].Chinese Journal of Birth Health & Heredity,2011(11):8-9. |
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| Authors: | WANG Li-xin YUAN Feng |
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| Affiliation: | WANG Li-xin,YUAN Feng.(The Affliated Hospital of Xuzhou Medical College,Xuzhou,China,221004) |
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| Abstract: | Ankylosing spondylitis is a highly genetic predisposition seronegative spondyloarthropathies.Previous studies mainly reported the strong association between HLA-B27 gene and AS,but in recent years a large number of studies suggest that besides HLA-B27 gene,there may be other MHC and non-MHC genes associated with AS.This article reviews the genetic progress of ankylosing spondylitis in order to provide new ideas to its diagnosis,prevention and treatment. |
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| Keywords: | Ankylosing spondylitis Genetic progress Gene |
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