舒芬太尼用于甲状腺手术的剂量探讨

目的探讨不同剂量舒芬太尼用于甲状腺手术的应用效果。方法将120例择期行甲状腺手术的患者随机分入Ⅰ组、Ⅱ组和Ⅲ组,每组40例。于术前5 min分别给予Ⅰ组,Ⅱ组,Ⅲ组舒芬太尼0.1,0.2,0.3μg/kg静脉注射。比较两组手术开始(T1)、术中牵拉甲状腺时(T2)及缝皮时(T3)血流动力学、镇静程度及镇痛评分的差异。结果Ⅱ组和Ⅲ组T1及T2时点平均动脉压(MAP)、心率(HR)显著低于Ⅰ组(P<0.05);在T1、T2及T3时点,Ⅱ组和Ⅲ组视觉模拟评分(VAS)及Ramsay评分显著优于Ⅰ组(P<0.05);Ⅲ组不良反应发生率显著高于Ⅰ组和Ⅱ组(P<0.05)。结论 0.2μg/kg的舒芬太尼持续输注镇痛、镇静效果好,不增加不良反应。

Study on Dose of Sufentanil Used in Thyroid Surgery

Objective To explore the effect of different doses of snfentanil used in thyroid surgery. Methods 120 cases undergoing elective thyroid surgery were randomly divided into the group Ⅰ, Ⅱ and Ⅲ with 40 cases in each group. The group Ⅰ, Ⅱ and m were given sufentanil 0. 1, 0. 2, 0. 3 μg/kg by intravenous injection at 5 rain before operation. The hemodynamics, degree of sedation and anal- gesic score at the operation beginning（T1） , thyroid traction during operation（T2） and skin suture（T3） were compared between two groups. Results The mean arterial pressure（MAP） and the heart rate （HR） at Tl and T2 in the group Ⅱ and Ⅲ were significantly lower than those in the group Ⅰ（ P 〈 0. 05）; the visual analogue scale（VAS） and the Ramsay scores at T1, T2 and T3 in the group Ⅱ and group Ⅲ were significantly superior to those in the group Ⅰ （P 〈 0. 05）; the occurrence rate of adverse reactions in the group Ⅲ were significantly higher than those in the group Ⅰ and Ⅱ（ P 〈 0. 05）. Conclusion The continuous infusion of sufentanil 0. 2 μg/kg has better analgesic and sedative effect without increasing adverse reactions