布地奈德联合特布他林治疗慢性阻塞性肺疾病急性加重期的效果研究

目的研究布地奈德联合特布他林治疗慢性阻塞性肺疾病急性加重期的效果。方法62例慢性阻塞性肺疾病急性加重期患者,随机分为对照组与实验组,每组31例。两组患者均进行吸氧与抗感染等基础治疗,对照组患者采用特布他林治疗,实验组患者采用布地奈德联合特布他林治疗。比较两组患者治疗效果及治疗前后二氧化碳分压。结果实验组患者治疗总有效率为87.10%,高于对照组的64.52%,差异具有统计学意义(P<0.05)。治疗前,两组患者二氧化碳分压比较差异无统计学意义(P>0.05);治疗后,两组患者二氧化碳分压均低于本组治疗前,且实验组患者二氧化碳分压(40.52±3.92)mm Hg(1 mm Hg=0.133 kPa)低于对照组的(54.53±4.81)mm Hg,差异具有统计学意义(P<0.05)。结论采用布地奈德联合特布他林治疗慢性阻塞性肺疾病急性加重期的效果显著,可以有效改善患者的血气指标,值得在临床上进行推广。

Study on the effect of budesonide combined with terbutaline in the treatment of acute exacerbation of chronic obstructive pulmonary disease

Objective To study the effect of budesonide combined with terbutaline in the treatment of acute exacerbation of chronic obstructive pulmonary disease.Methods A total of 62 patients with acute exacerbation of chronic obstructive pulmonary disease were randomly divided into control group and experimental group,with 31 cases in each group.Both groups received basic treatments of oxygen inhalation and antiinfection.The control group was treated with terbutaline,and the experimental group was treated with budesonide combined with terbutaline.The therapeutic effect and carbon dioxide partial pressure before and after treatment were compared between the two groups.Results The total effective rate of treatment of the experimental group was 87.10%,which was higher than 64.52%of the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference in carbon dioxide partial pressure between the two groups(P>0.05).After treatment,the carbon dioxide partial pressure of the two groups were lower than those before treatment,and the carbon dioxide partial pressure(40.52±3.92)mm Hg(1 mm Hg=0.133 kPa)of the experimental group was lower than(54.53±4.81)mm Hg of the control group,and the difference was statistically significant(P<0.05).Conclusion Budesonide combined with terbutaline has remarkable effect in the treatment of acute exacerbation of chronic obstructive pulmonary disease,and it can effectively improve the blood gas index of patients.It is worthy of clinical promotion.