| 成人万古霉素血药浓度监测的探讨 |
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| 引用本文： | 张抗怀,黄泰康. 成人万古霉素血药浓度监测的探讨[J]. 中国临床药理学杂志, 2010, 26(2) |
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| 作者姓名： | 张抗怀 黄泰康 |
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| 作者单位： | 1. 沈阳药科大学,现代社会药学研究中心,沈阳,110016;西安交通大学,医学院,第二附属医院,药剂科,西安,710004
2. 国家食品药品监督管理局,北京,100810 |
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| 摘 要： | 万古霉素(糖肽类抗生素)是治疗耐甲氧西林金黄色葡萄球菌(MRSA)感染的主要药物之一。进行血药浓度监测,能降低毒性和提高疗效。AUC/MIC是预测万古霉素疗效的重要参数,监测谷浓度是最为准确和实用的方法;但并非所有患者都必须进行监测。应继续开展相关研究,促进万古霉素临床使用安全、有效。
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| 关 键 词： | 万古霉素 治疗药物监测 肾毒性 |
Discussion about therapeutic monitoring of vancomycin in adult |
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| ZHANG Kang-huai,HUANG Tai-kang. Discussion about therapeutic monitoring of vancomycin in adult[J]. The Chinese Journal of Clinical Pharmacology, 2010, 26(2) |
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| Authors: | ZHANG Kang-huai HUANG Tai-kang |
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| Affiliation: | 1.Modern Social Pharmaceutical Research Center of Shengyang Pharmaceutical University;Shengyang 110016;China;2.Department of Pharmacy;The Second Hospital of Medical College of Xi'an Jiaotong University;Xi'an;710004;3.State Food and Drug Administration;Beijing 100810;China |
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| Abstract: | Vancomycin is one of important antibiotics against methicillin resistant Staphylococcus aureus(MRSA)infections.Therapeutic monitoring of vancomycin has been advocated to lessen the potential toxicity and to achieve therapeutic concentrations.Reviews of previous articles have recommended the AUC/MIC as the preferred predictive parameter for vancomycin and trough serum concentrations as the most accurate and practical method for monitoring vancomycin effectiveness.Monitoring of serum vancomycin concentrations... |
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| Keywords: | vancomycin therapeutic drug monitoring nephrotoxicity |
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