| 胰岛素样生长因子Ⅱ在肝细胞癌的免疫组化研究 |
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| 引用本文： | 张遂祥,苏勤.胰岛素样生长因子Ⅱ在肝细胞癌的免疫组化研究[J].临床与实验病理学杂志,1993,9(3):161-163,T001. |
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| 作者姓名： | 张遂祥 苏勤 |
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| 作者单位： | 第四军医大学 西安710038
(张遂祥，苏勤，刘彦仿，李德芳)，第四军医大学 西安710038(张劲风) |
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| 摘 要： | 以兔抗胰岛素样生长因子Ⅱ(IGF-2)的抗体,ABC法,对50例肝癌石蜡切片染色,结果:(1)正常肝有极微弱阳性,表明可分泌少量IGF-2;(2)癌旁肝27例,全部阳性,“++”者19例(70%),表明有大量IGF-2产生和存在;(3)50例肝癌,48例(96%)阳性,IGF-2呈胞浆弥散型分布,其中26例(52%)呈较强阳性(++),8例核内也有IGF-2,表明癌细胞能自己合成IGF-2为其恶性增殖创造条件,且不因分化程度之降低而有所减少;(4)IGF-2呈较强阳性(++)之细胞(包括小多角形肝细胞)既见于癌周肝,又见于慢性肝炎,表明胰岛素样生长因子Ⅱ直接和增殖而非与癌变相关。
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| 关 键 词： | 肝细胞癌 IGF－2 免疫组织化学 |
Immunohistochemical Study of Insulin-like Growth Factor 2 in Hepatocellular Carcinoma |
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| Zhang Suixiang et al The Fourth Military Medical University,Xian.Immunohistochemical Study of Insulin-like Growth Factor 2 in Hepatocellular Carcinoma[J].Chinese Journal of Clinical and Experimental Pathology,1993,9(3):161-163,T001. |
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| Authors: | Zhang Suixiang The Fourth Military Medical University Xian |
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| Affiliation: | Zhang Suixiang et al The Fourth Military Medical University,Xian 710038 |
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| Abstract: | Paraffin sections of 50 cases of hepatocellular carcinoma were immunostained by ABCmethod using antibody against insulin-like growth factor 2(IGF-2).The results showed:(1)normalhepatic tissue is weakly positive;(2)27 cases of hepatic tissue near carcinoma are all positive,19 cas-es(70%)are more intense(++);(3)48 cases(96%)of hepatocellular carcinoma are positive,26cases(52%)are more intense(++);(4)the cells which expressed more intense IGF-2 appeared notonly in carcinomas but also in non carcinoma(such as chronic hepatitis)reflecting that IGF-2 does notdirectly related to anaplasia but proliferation. |
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| Keywords: | hepatocellular carcinoma immunohistochemistry IGF-2 |
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