On the Relationship between Dynamic Contrast-Enhanced Ultrasound Parameters and the Underlying Vascular Architecture Extracted from Acoustic Angiography |
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Authors: | Anastasiia Panfilova Sarah E Shelton Cristina Caresio Ruud JG van Sloun Filippo Molinari Hessel Wijkstra Paul A Dayton Massimo Mischi |
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Affiliation: | 2. Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Chapel Hill, North Carolina, USA;3. Politecnico di Torino, Torino, Italy;4. Urology Department, AMC University Hospital, Amsterdam, The Netherlands |
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Abstract: | Dynamic contrast-enhanced ultrasound (DCE-US) has been proposed as a powerful tool for cancer diagnosis by estimation of perfusion and dispersion parameters reflecting angiogenic vascular changes. This work was aimed at identifying which vascular features are reflected by the estimated perfusion and dispersion parameters through comparison with acoustic angiography (AA). AA is a high-resolution technique that allows quantification of vascular morphology. Three-dimensional AA and 2-D DCE-US bolus acquisitions were used to monitor the growth of fibrosarcoma tumors in nine rats. AA-derived vascular properties were analyzed along with DCE-US perfusion and dispersion to investigate the differences between tumor and control and their evolution in time. AA-derived microvascular density and DCE-US perfusion exhibited good agreement, confirmed by their spatial distributions. No vascular feature was correlated with dispersion. Yet, dispersion provided better cancer classification than perfusion. We therefore hypothesize that dispersion characterizes vessels that are smaller than those visible with AA. |
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Keywords: | Acoustic angiography Dynamic contrast-enhanced ultrasound Cancer Dispersion Perfusion Ultrasound contrast agents |
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