Synthesis of 1H-pyrazole-1-carboxamide derivatives and their antiproliferative activity against melanoma cell line |
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Authors: | El-Gamal Mohammed I Sim Tae Bo Hong Jun Hee Cho Jung-Hyuck Yoo Kyung Ho Oh Chang-Hyun |
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Affiliation: | Biomaterials Center, Korea Institute of Science and Technology, Cheongryang, Seoul, Republic of Korea. |
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Abstract: | Synthesis of a new series of 1H-pyrazole-1-carboxamide derivatives is described. Their antiproliferative activity against A375 human melanoma cell line was tested and the effect of substituents on the diarylpyrazole scaffold was investigated. The pharmacological results indicated that most of the newly synthesized compounds showed moderate activity against A375, compared with sorafenib. Among all of these derivatives, compound IIe which has N-methylpiperazinyl and phenolic moieties showed the most potent antiproliferative activity against A375 human melanoma cell line. |
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Keywords: | A375 Antiproliferative activity 3 4‐Diarylpyrazole Melanoma 1H‐Pyrazole‐1‐carboxamide |
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